Micro total analysis systems. 2. Analytical standard operations and applications

PA Auroux, D Iossifidis, DR Reyes, A Manz - Analytical chemistry, 2002 - ACS Publications
After having reviewed some aspects of microfluidic system preparation in the first part (1), in
this second part of the review we will cover a number of standard operations (namely …

PCR microfluidic devices for DNA amplification

C Zhang, J Xu, W Ma, W Zheng - Biotechnology advances, 2006 - Elsevier
The miniaturization of biological and chemical analytical devices by micro-electro-
mechanical-systems (MEMS) technology has posed a vital influence on such fields as …

Integrated system for rapid PCR-based DNA analysis in microfluidic devices

J Khandurina, TE McKnight, SC Jacobson… - Analytical …, 2000 - ACS Publications
An integrated system for rapid PCR-based analysis on a microchip has been demonstrated.
The system couples a compact thermal cycling assembly based on dual Peltier …

Microfluidic chips for clinical and forensic analysis

E Verpoorte - Electrophoresis, 2002 - Wiley Online Library
This review gives an overview of developments in the field of microchip analysis for clinical
diagnostic and forensic applications. The approach chosen to review the literature is …

Single-molecule DNA amplification and analysis in an integrated microfluidic device

ET Lagally, I Medintz, RA Mathies - Analytical chemistry, 2001 - ACS Publications
Stochastic PCR amplification of single DNA template molecules followed by capillary
electrophoretic (CE) analysis of the products is demonstrated in an integrated microfluidic …

Microchips, microarrays, biochips and nanochips: personal laboratories for the 21st century

LJ Kricka - Clinica Chimica Acta, 2001 - Elsevier
Micro miniaturization of analytical procedures is having significant impact on diagnostic
testing, and will enable highly complex clinical testing to be miniaturized and permit testing …

Total nucleic acid analysis integrated on microfluidic devices

L Chen, A Manz, PJR Day - Lab on a Chip, 2007 - pubs.rsc.org
The design and integration of microfluidic devices for on-chip amplification of nucleic acids
from various biological samples has undergone extensive development. The actual benefit …

Microchip pcr

LJ Kricka, P Wilding - Analytical and Bioanalytical Chemistry, 2003 - Springer
Miniaturization of genetic tests has become an important goal. This review surveys the
current progress towards the miniaturization of tests based on the polymerase chain reaction …

DNA sequencing and genotyping in miniaturized electrophoresis systems

CW Kan, CP Fredlake, EAS Doherty… - Electrophoresis, 2004 - Wiley Online Library
Advances in microchannel electrophoretic separation systems for DNA analyses have had
important impacts on biological and biomedical sciences, as exemplified by the successes …

[PDF][PDF] Fundamental principles and applications of microfluidic systems

SE Ong, S Zhang, H Du, Y Fu - Front. Biosci, 2008 - academia.edu
Introduction 3. Fluid flow 3.1. Fluid Characteristics 3.2. Flow Characteristics 4. Transport
mechanisms 4.1. Convection 4.2. Migration 4.3. Diffusion 4.3. 1. Temperature dependence …