This review critically summarizes the neuropathology and genetics of schizophrenia, the
relationship between them, and speculates on their functional convergence. The …

Neuronal nicotinic receptors (NAChRs) form a heterogeneous family of ion channels that are
differently expressed in many regions of the central nervous system (CNS) and peripheral …

Alzheimer's disease pathology is characterized by the presence of neuritic plaques and the
loss of cholinergic neurons in the brain. The underlying mechanisms leading to these events …

Abstract We identified 15q13. 3 microdeletions encompassing the CHRNA7 gene in 12 of
1,223 individuals with idiopathic generalized epilepsy (IGE), which were not detected in …

Neuronal nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels that are
widely distributed both pre-and post-synaptically in the mammalian brain. By modulating …

Alzheimer's Disease (AD) is the most common of the senile dementias, the prevalence of
which is increasing rapidly, with a projected 14 million affected worldwide by 2025. The …

Amyloid β1–42, a major component of amyloid plaques, binds with exceptionally high affinity
to the α7 nicotinic acetylcholine receptor and accumulates intracellularly in neurons of …

It is easy to create new combinatorial games but more difficult to predict those that will
interest human players. We examine the concept of game quality, its automated …

We have recently reported evidence that a very high affinity interaction between the β‐
amyloid peptide Aβ1‐42 and the α7 nicotinic acetylcholine receptor (α7nAChR) may be a …

Nicotinic acetylcholine receptors (nAChRs) are integral membrane proteins and prototypic
members of the ligand‐gated ion‐channel superfamily, which has precursors in the …