Lineage studies conducted in the retina more than 25 years ago demonstrated the
multipotency of retinal progenitor cells (RPCs). The number and types of cells produced by …

Self-organization is a process that ensures histogenesis of the eye retina. This highly
intricate phenomenon is not sufficiently studied due to its biological complexity and genetic …

ABSTRACT Proneural basic Helix-Loop-Helix (bHLH) proteins are required for neuronal
determination and the differentiation of most neural precursor cells. These transcription …

Retinal ganglion cells (RGCs) relay visual information from the eye to the brain. RGCs are
the first cell type generated during retinal neurogenesis. Loss of function of the transcription …

The vertebrate retina is regarded as a simple part of the central nervous system (CNS) and
thus amenable to investigations of the determinants of cell fate. Its five neuronal cell classes …

To develop biological approaches to restore vision, we developed a method of transplanting
stem cell-derived retinal tissue into the subretinal space of a large-eye animal model (cat) …

Somatosensory, taste, vestibular, and auditory information is first processed in the
brainstem. From the brainstem, the respective information is relayed to specific regions …

The mammalian inner ear develops from a placodal thickening into a complex labyrinth of
ducts with five sensory organs specialized to detect position and movement in space. The …

Stem cell-based therapy of retinal degenerative conditions is a promising modality to treat
blindness, but requires new strategies to improve the number of functionally integrating …

Glaucoma, the second leading cause of blindness worldwide, is an incurable
neurodegenerative disorder due to the dysfunction of retinal ganglion cells (RGCs). RGCs …