In contrast to their role in cell types with higher energy demands, mitochondria in endothelial
cells primarily function in signaling cellular responses to environmental cues. This article …

Oxygen is essential for eukaryotic life and is inextricably linked to the evolution of
multicellular organisms. Proper cellular response to changes in oxygen tension during …

Numerous molecular abnormalities have been described in pulmonary arterial hypertension
(PAH), complicating the translation of candidate therapies to patients because, typically, 1 …

Once thought of as toxic by-products of cellular metabolism, reactive oxygen species (ROS)
have been implicated in a large variety of cell-signaling processes. Several enzymatic …

The eukaryote's mitochondrial network is perhaps the cell's most sophisticated and dynamic
responsive sensing system. Integrating metabolic, oxygen, or danger signals with inputs …

Despite significant progress in cardiovascular medicine, myocardial ischemia and infarction,
progressing eventually to the final end point heart failure (HF), remain the leading cause of …

The uncoupling proteins (UCPs) are attracting an increased interest as potential therapeutic
targets in a number of important diseases. UCP2 is expressed in several tissues, but its …

Rationale: Mitochondrial signaling regulates both the acute and the chronic response of the
pulmonary circulation to hypoxia, and suppressed mitochondrial glucose oxidation …

Uncoupling protein 2 (UCP2) is an inner mitochondrial membrane protein that belongs to
the uncoupling protein family and plays an important role in lowering mitochondrial …

Endothelial cells play an important physiological role in vascular homeostasis. They are also
the first barrier that separates blood from deeper layers of blood vessels and extravascular …