How to enter a bacterium: bacterial porins and the permeation of antibiotics
JD Prajapati, U Kleinekathöfer… - Chemical …, 2021 - ACS Publications
Despite tremendous successes in the field of antibiotic discovery seen in the previous
century, infectious diseases have remained a leading cause of death. More specifically …
century, infectious diseases have remained a leading cause of death. More specifically …
Understanding antibiotic resistance via outer membrane permeability
I Ghai, S Ghai - Infection and drug resistance, 2018 - Taylor & Francis
Collective antibiotic drug resistance is a global threat, especially with respect to Gram-
negative bacteria. The low permeability of the bacterial outer cell wall has been identified as …
negative bacteria. The low permeability of the bacterial outer cell wall has been identified as …
Nanomaterials and molecular transporters to overcome the bacterial envelope barrier: Towards advanced delivery of antibiotics
RS Santos, C Figueiredo, NF Azevedo… - Advanced drug delivery …, 2018 - Elsevier
With the dramatic consequences of bacterial resistance to antibiotics, nanomaterials and
molecular transporters have started to be investigated as alternative antibacterials or anti …
molecular transporters have started to be investigated as alternative antibacterials or anti …
The antibacterial activity of metal complexes containing 1, 10-phenanthroline: potential as alternative therapeutics in the era of antibiotic resistance
L Viganor, O Howe, P McCarron… - Current topics in …, 2017 - ingentaconnect.com
The “antibiotic era”, characterized by the overuse and misuse of antibiotics, over the last half-
century has culminated in the present critical “era of resistance”. The treatment of bacterial …
century has culminated in the present critical “era of resistance”. The treatment of bacterial …
A monodisperse transmembrane α-helical peptide barrel
The fabrication of monodisperse transmembrane barrels formed from short synthetic
peptides has not been demonstrated previously. This is in part because of the complexity of …
peptides has not been demonstrated previously. This is in part because of the complexity of …
Identifying glycan consumers in human gut microbiota samples using metabolic labeling coupled with fluorescence-activated cell sorting
L Dridi, F Altamura, E Gonzalez, O Lui… - Nature …, 2023 - nature.com
The composition and metabolism of the human gut microbiota are strongly influenced by
dietary complex glycans, which cause downstream effects on the physiology and health of …
dietary complex glycans, which cause downstream effects on the physiology and health of …
Bacterial outer membrane porins as electrostatic nanosieves: exploring transport rules of small polar molecules
Transport of molecules through biological membranes is a fundamental process in biology,
facilitated by selective channels and general pores. The architecture of some outer …
facilitated by selective channels and general pores. The architecture of some outer …
Interaction of Tryptophan- and Arginine-Rich Antimicrobial Peptide with E. coli Outer Membrane—A Molecular Simulation Approach
A short antimicrobial peptide (AMP), rich in tryptophan and arginine (P6—HRWWRWWRR-
NH2), was used in molecular dynamics (MD) simulations to investigate the interaction …
NH2), was used in molecular dynamics (MD) simulations to investigate the interaction …
Sensing PEGylated Peptide Conformations Using a Protein Nanopore
Membrane pores are exploited for the stochastic sensing of various analytes, and here, we
use electrical recordings to explore the interaction of PEGylated peptides of different sizes …
use electrical recordings to explore the interaction of PEGylated peptides of different sizes …