Human immunodeficiency virus type 1 (HIV-1) replication is a highly regulated process
requiring the recruitment of viral and cellular components to the plasma membrane for …

The genome of the retroviruses is a dimer composed by two homologous copies of genomic
RNA (gRNA) molecules of positive polarity. The dimerization process allows two gRNA …

The dynamics and regulation of HIV-1 nuclear import and its intranuclear movements after
import have not been studied. To elucidate these essential HIV-1 post-entry events, we …

Many eukaryotic RNA viruses transcribe subgenomic (sg) mRNAs during infections to
control expression of a subset of viral genes. Such transcriptional events are commonly …

To generate infectious virus, HIV-1 must package two copies of its full-length RNA into
particles. HIV-1 transcription initiates from multiple, neighboring sites, generating RNA …

During retroviral replication, the full-length RNA serves both as mRNA and genomic RNA.
However, the mechanisms by which the HIV-1 Gag protein selects the two RNA molecules …

The packaging and budding of Gag polyprotein and viral RNA is a critical step in the HIV-1
life cycle. High-resolution structures of the Gag polyprotein have revealed that the capsid …

Assembly of HIV-1 particles is initiated by the trafficking of viral Gag polyproteins from the
cytoplasm to the plasma membrane, where they co-localize and bud to form immature …

Members of the family Retroviridae are important animal and human pathogens. Being
obligate parasites, their replication involves a series of steps during which the virus hijacks …

Like other retroviruses, human immunodeficiency virus type 1 (HIV-1) selectively packages
genomic RNA (gRNA) during virus assembly. However, in the absence of the gRNA, cellular …