The life-cycle of the HIV-1 Gag–RNA complex
E Mailler, S Bernacchi, R Marquet, JC Paillart… - Viruses, 2016 - mdpi.com
Human immunodeficiency virus type 1 (HIV-1) replication is a highly regulated process
requiring the recruitment of viral and cellular components to the plasma membrane for …
requiring the recruitment of viral and cellular components to the plasma membrane for …
Retroviral RNA dimerization: from structure to functions
N Dubois, R Marquet, JC Paillart… - Frontiers in …, 2018 - frontiersin.org
The genome of the retroviruses is a dimer composed by two homologous copies of genomic
RNA (gRNA) molecules of positive polarity. The dimerization process allows two gRNA …
RNA (gRNA) molecules of positive polarity. The dimerization process allows two gRNA …
Dynamics and regulation of nuclear import and nuclear movements of HIV-1 complexes
RC Burdick, KA Delviks-Frankenberry, J Chen… - PLoS …, 2017 - journals.plos.org
The dynamics and regulation of HIV-1 nuclear import and its intranuclear movements after
import have not been studied. To elucidate these essential HIV-1 post-entry events, we …
import have not been studied. To elucidate these essential HIV-1 post-entry events, we …
Dimerization of an umbravirus RNA genome activates subgenomic mRNA transcription
T Chkuaseli, KA White - Nucleic Acids Research, 2023 - academic.oup.com
Many eukaryotic RNA viruses transcribe subgenomic (sg) mRNAs during infections to
control expression of a subset of viral genes. Such transcriptional events are commonly …
control expression of a subset of viral genes. Such transcriptional events are commonly …
Selective packaging of HIV-1 RNA genome is guided by the stability of 5′ untranslated region polyA stem
OA Nikolaitchik, S Liu, JP Kitzrow… - Proceedings of the …, 2021 - National Acad Sciences
To generate infectious virus, HIV-1 must package two copies of its full-length RNA into
particles. HIV-1 transcription initiates from multiple, neighboring sites, generating RNA …
particles. HIV-1 transcription initiates from multiple, neighboring sites, generating RNA …
Epitranscriptomic regulation of HIV-1 full-length RNA packaging
C Pereira-Montecinos, D Toro-Ascuy… - Nucleic Acids …, 2022 - academic.oup.com
During retroviral replication, the full-length RNA serves both as mRNA and genomic RNA.
However, the mechanisms by which the HIV-1 Gag protein selects the two RNA molecules …
However, the mechanisms by which the HIV-1 Gag protein selects the two RNA molecules …
Immature HIV-1 lattice assembly dynamics are regulated by scaffolding from nucleic acid and the plasma membrane
AJ Pak, JMA Grime, P Sengupta… - Proceedings of the …, 2017 - National Acad Sciences
The packaging and budding of Gag polyprotein and viral RNA is a critical step in the HIV-1
life cycle. High-resolution structures of the Gag polyprotein have revealed that the capsid …
life cycle. High-resolution structures of the Gag polyprotein have revealed that the capsid …
Structural and molecular determinants of membrane binding by the HIV-1 matrix protein
PY Mercredi, N Bucca, B Loeliger, CR Gaines… - Journal of molecular …, 2016 - Elsevier
Assembly of HIV-1 particles is initiated by the trafficking of viral Gag polyproteins from the
cytoplasm to the plasma membrane, where they co-localize and bud to form immature …
cytoplasm to the plasma membrane, where they co-localize and bud to form immature …
[HTML][HTML] Understanding retroviral life cycle and its genomic RNA packaging
Members of the family Retroviridae are important animal and human pathogens. Being
obligate parasites, their replication involves a series of steps during which the virus hijacks …
obligate parasites, their replication involves a series of steps during which the virus hijacks …
On the selective packaging of genomic RNA by HIV-1
M Comas-Garcia, SR Davis, A Rein - Viruses, 2016 - mdpi.com
Like other retroviruses, human immunodeficiency virus type 1 (HIV-1) selectively packages
genomic RNA (gRNA) during virus assembly. However, in the absence of the gRNA, cellular …
genomic RNA (gRNA) during virus assembly. However, in the absence of the gRNA, cellular …