The extracellular matrix (ECM) is an essential component of the heart that imparts
fundamental cellular processes during organ development and homeostasis. Most …

In the setting of myocardial infarction (MI), ischemia reperfusion injury (IRI) occurs due to
occlusion (ischemia) and subsequent re-establishment of blood flow (reperfusion) of a …

Macrophages sense changes in the extracellular matrix environment through the integrins
and play a central role in regulation of the reparative response after myocardial infarction …

Epithelial-to-mesenchymal transitions (EMTs) and extracellular matrix (ECM) remodeling are
distinct yet important processes during carcinoma invasion and metastasis. Transforming …

Background: Remodeling of the extracellular matrix (ECM) is a hallmark of heart failure (HF).
Our previous analysis of the secretome of murine cardiac fibroblasts returned ADAMTS5 (a …

The extracellular matrix (ECM) is the noncellular component of tissues in the cardiovascular
system and other organs throughout the body. It is formed of filamentous proteins …

Macrophages are components of the innate immune system with key roles in tissue
inflammation and repair. It is now evident that macrophages also support organogenesis …

The regeneration of smooth muscle with physiological functions has been a key challenge in
vascular tissue engineering. Hyaluronan (HA), as a major component of the extracellular …

Following acute occlusion of a coronary artery causing myocardial ischemia and
implementing first-line treatment involving rapid reperfusion, a dynamic and balanced …

Background Tumour necrosis factor superfamily protein 14 (TNFSF14), also called LIGHT, is
an important regulator of immunological and fibrosis diseases. However, its specific …