The native chemical ligation reaction (NCL) involves reacting a C-terminal peptide thioester
with an N-terminal cysteinyl peptide to produce a native peptide bond between the two …

Limited understanding of human proteoforms with complex posttranslational modifications
and the underlying mechanisms poses a major obstacle to research on human health and …

The N-degron pathway targets proteins that bear a destabilizing residue at the N terminus
for proteasome-dependent degradation. In yeast, Ubr1—a single-subunit E3 ligase—is …

Contemporary chemical protein synthesis has been dramatically advanced over the past few
decades, which has enabled chemists to reach the landscape of synthetic …

The chemical synthesis of homogeneously modified histones is a powerful approach to
quantitatively decipher how post-translational modifications (PTMs) modulate epigenetic …

D‐peptide ligands can be screened for therapeutic potency and enzymatic stability using
synthetic mirror‐image proteins (D‐proteins), but efficient acquisition of these D‐proteins …

Nature has developed a plethora of protein machinery to operate and maintain nearly every
task of cellular life. These processes are tightly regulated via post‐expression modifications …

The central dogma of modern biology underscores the pivotal roles proteins play in diverse
biological processes, the study of which necessitates advanced methods to produce …

Total chemical protein synthesis provides access to entire D‐protein enantiomers enabling
unique applications in molecular biology, structural biology, and bioactive compound …

Highlights•Cell-autonomous immunity senses, signals, and eliminates intracellular
pathogens.•Ubiquitination is a post-translational modification that connects these pathways.• …