The HERC gene family encodes proteins with two characteristic domains in their sequence:
the HECT domain and the RCC1-like domain (RLD). In humans, the HERC family comprises …

Alzheimer's disease (AD) is a progressive neurodegenerative disease in which the
formation of extracellular aggregates of amyloid beta (Aβ) peptide, fibrillary tangles of …

Molecular diversity of microglia, the resident immune cells in the CNS, is reported. Whether
microglial subsets characterized by the expression of specific proteins constitute subtypes …

The ubiquitin-proteasome system (UPS) mediated protein degradation is crucial to maintain
quantitive and functional homeostasis of diverse proteins. Balanced cellular protein …

Febrile seizures represent the most common type of pathological brain activity in young
children and are influenced by genetic, environmental and developmental factors. In a …

Circular RNAs (circRNAs) are emerging as a novel, yet powerful player in many human
diseases. They are involved in several cellular processes and are becoming a noteworthy …

The HERC protein family is one of three subfamilies of Homologous to E6AP C-terminus
(HECT) E3 ubiquitin ligases. Six HERC genes have been described in humans, two of which …

Neuromuscular disorders (NMDs) affect 1 in 3000 people worldwide. There are more than
150 different types of NMDs, where the common feature is the loss of muscle strength. These …

Homologous to the E6AP carboxyl terminus (HECT) and regulator of chromosome
condensation 1 (RCC1)-like domain-containing proteins (HERCs) belong to the superfamily …

Background Aetiological diagnosis in non‐syndromic intellectual disability (NSID) still poses
a diagnostic challenge to clinicians. Methods Screening is currently achieved by …