Detection technologies for RNA modifications
Y Zhang, L Lu, X Li - Experimental & Molecular Medicine, 2022 - nature.com
To date, more than 170 chemical modifications have been characterized in RNA, providing a
new layer of gene expression regulation termed the 'epitranscriptome'. RNA modification …
new layer of gene expression regulation termed the 'epitranscriptome'. RNA modification …
Roles and regulation of tRNA-derived small RNAs in animals
S Muthukumar, CT Li, RJ Liu, C Bellodi - Nature Reviews Molecular Cell …, 2024 - nature.com
A growing class of small RNAs, known as tRNA-derived RNAs (tdRs), tRNA-derived small
RNAs or tRNA-derived fragments, have long been considered mere intermediates of tRNA …
RNAs or tRNA-derived fragments, have long been considered mere intermediates of tRNA …
Transcription factors interact with RNA to regulate genes
O Oksuz, JE Henninger, R Warneford-Thomson… - Molecular cell, 2023 - cell.com
Transcription factors (TFs) orchestrate the gene expression programs that define each cell's
identity. The canonical TF accomplishes this with two domains, one that binds specific DNA …
identity. The canonical TF accomplishes this with two domains, one that binds specific DNA …
Aberrant translation regulated by METTL1/WDR4‐mediated tRNA N7‐methylguanosine modification drives head and neck squamous cell carcinoma progression
J Chen, K Li, J Chen, X Wang, R Ling… - Cancer …, 2022 - Wiley Online Library
Background Cancer cells selectively promote the translation of oncogenic transcripts to
stimulate cancer progression. Although growing evidence has revealed that tRNA …
stimulate cancer progression. Although growing evidence has revealed that tRNA …
Selective advantage of mutant stem cells in human clonal hematopoiesis is associated with attenuated response to inflammation and aging
Clonal hematopoiesis (CH) arises when hematopoietic stem cells (HSCs) acquire mutations,
most frequently in the DNMT3A and TET2 genes, conferring a competitive advantage …
most frequently in the DNMT3A and TET2 genes, conferring a competitive advantage …
Denaturing purifications demonstrate that PRC2 and other widely reported chromatin proteins do not appear to bind directly to RNA in vivo
Summary Polycomb repressive complex 2 (PRC2) is reported to bind to many RNAs and
has become a central player in reports of how long non-coding RNAs (lncRNAs) regulate …
has become a central player in reports of how long non-coding RNAs (lncRNAs) regulate …
RNA methylation in mammalian development and cancer
P Song, S Tayier, Z Cai, G Jia - Cell Biology and Toxicology, 2021 - Springer
Similar to epigenetic DNA and histone modifications, epitranscriptomic modifications (RNA
modifications) have emerged as crucial regulators in temporal and spatial gene expression …
modifications) have emerged as crucial regulators in temporal and spatial gene expression …
TET2-mediated mRNA demethylation regulates leukemia stem cell homing and self-renewal
TET2 is recurrently mutated in acute myeloid leukemia (AML) and its deficiency promotes
leukemogenesis (driven by aggressive oncogenic mutations) and enhances leukemia stem …
leukemogenesis (driven by aggressive oncogenic mutations) and enhances leukemia stem …
TET (Ten-eleven translocation) family proteins: structure, biological functions and applications
X Zhang, Y Zhang, C Wang, X Wang - Signal Transduction and …, 2023 - nature.com
Ten-eleven translocation (TET) family proteins (TETs), specifically, TET1, TET2 and TET3,
can modify DNA by oxidizing 5-methylcytosine (5mC) iteratively to yield 5 …
can modify DNA by oxidizing 5-methylcytosine (5mC) iteratively to yield 5 …
Reactivity-dependent profiling of RNA 5-methylcytidine dioxygenases
Epitranscriptomic RNA modifications can regulate fundamental biological processes, but we
lack approaches to map modification sites and probe writer enzymes. Here we present a …
lack approaches to map modification sites and probe writer enzymes. Here we present a …