Cell death is critical for the development and homeostasis of almost all multicellular
organisms. Moreover, its dysregulation leads to diverse disease states. Historically …

Regulated cell death (RCD) relies on activation and recruitment of pore-forming proteins
(PFPs) that function as executioners of specific cell death pathways: apoptosis regulator …

Cell death is a fundamental physiological process in all living organisms. Its roles extend
from embryonic development, organ maintenance, and aging to the coordination of immune …

Plant nucleotide-binding leucine-rich repeat receptors (NLRs) regulate immunity and cell
death. In Arabidopsis, a subfamily of “helper” NLRs is required by many “sensor” NLRs …

Necroptosis, a form of programmed necrotic cell death, is a gatekeeper of host defense
against certain pathogen invasions. The deregulation of necroptosis is also a key factor of …

Cell death is an essential process in all living organisms and occurs through different
mechanisms. The three main types of programmed cell death are apoptosis, pyroptosis, and …

Small cell lung cancer (SCLC) is an aggressive form of lung cancer characterized by dismal
prognosis. Although SCLC may initially respond well to platinum-based chemotherapy, it …

Atherosclerosis is a chronic inflammatory disease characterized by the accumulation of fatty
deposits in the inner walls of vessels. These plaques restrict blood flow and lead to …

Cell suicide pathways, termed regulated cell death (RCD), play a critical role in organismal
development, homeostasis, and pathogenesis. Here, we provide an overview of key RCD …

New research has shown that the development of osteoarthritis (OA) is regulated by different
mechanisms of cell death and types of cytokines. Therefore, elucidating the mechanism of …