Background The collagen receptor glycoprotein VI (GPVI) is an attractive antiplatelet target
due to its critical role in thrombosis but minor involvement in hemostasis. Objective To …

In platelets, elevated cytosolic Ca 2+ is a crucial second messenger, involved in most
functional responses, including shape change, secretion, aggregation and procoagulant …

Distinct platelet activation patterns are elicited by the tyrosine kinase-linked collagen
receptor glycoprotein VI (GPVI) and the G-protein coupled protease-activated receptors …

Hypo-and hyperthermia affect both primary and secondary hemostasis; however, there are
controversial data concerning platelet activation and the underlying mechanisms under …

Background Platelet glycoprotein VI (GPVI) stimulation activates the tyrosine kinases Syk
and Btk, and the effector proteins phospholipase Cγ 2 (PLCγ2) and protein kinase C (PKC) …

Platelets play a critical role in hemostasis and thrombosis; therefore, in vitro assays that
measure platelet reactivity are fundamental tools to gain insight into these physiologic …

Glycoprotein (GP) VI and integrin αIIbβ3 are key signaling receptors in collagen-dependent
platelet aggregation and in arterial thrombus formation under shear. The multiple …

The endothelial regulation of platelet activity is incompletely understood. Here we describe
novel approaches to find molecular pathways implicated on the platelet–endothelium …

Тромбоциты–безъядерные клетки крови размером 2-4 мкм, производящиеся в костном
мозге и циркулирующие в кровотоке в течение 7-10 дней до момента утилизации в …