The use of psychoactive drugs is a wide spread behaviour in human societies. The
systematic use of a drug requires the establishment of different drug use-associated …

Cocaine exhibits prominent abuse liability, and chronic abuse can result in cocaine use
disorder with significant morbidity. Major advances have been made in delineating …

Most psychostimulants interact with monoamine transport proteins. This paper reviews work
our laboratory has conducted to investigate the interaction of psychostimulants with …

Examines the hypothesis that negative affective states can contribute to the reinforcement
associated with drug taking by changing the set point for hedonic processing or the set point …

Serotonin1A-receptors (5-HT1A-Rs) are important components of the 5-HT system in the
brain. As somatodendritic autoreceptors they control the activity of 5-HT neurons, and, as …

Several previous studies show a relationship between impulsivity and substance abuse;
however, it is unclear whether the increased impulsivity seen in substance dependent …

OBJECTIVE: Earlier platelet and postmortem brain studies have found alterations in
serotonin transporter function in ethanol-abusing human subjects. The present investigation …

The mesocorticolimbic dopamine system, which arises in the ventral tegmental area and
innervates the nucleus accumbens, among numerous other regions, has been implicated in …

A number of untreated or inadequately treated psychiatric illnesses often demonstrate
syndrome progression manifested by either increasing frequency, severity, or spontaneity of …

Alterations in dopamine transmission in the nucleus accumbens, which is composed of two
anatomically distinct compartments termed the shell and core, contribute to the expression of …