Erythropoiesis is a multi‐step process that involves the differentiation of hematopoietic stem
cells into mature red blood cells (RBCs). This process is regulated by several signaling …

Abstract α-Thalassemia is an inherited, autosomal recessive, disorder characterized by a
microcytic hypochromic anemia. It is one of the most common monogenic gene disorders in …

Single-cell RNA sequencing studies of differentiating systems have raised fundamental
questions regarding the discrete versus continuous nature of both differentiation and cell …

A goal of single-cell genome-wide profiling is to reconstruct dynamic transitions during cell
differentiation, disease onset and drug response. Single-cell assays have recently been …

Through their oxygen delivery function, red blood cells are pivotal to the healthy existence of
all vertebrate organisms. These cells are required during all stages of life—embryonic, fetal …

Hematopoiesis is a complex process with a variety of different signaling pathways
influencing every step of blood cell formation from the earliest precursors to final …

Hematopoietic stem and progenitor cells (HSPCs) in the bone marrow are derived from a
small population of hemogenic endothelial (HE) cells located in the major arteries of the …

Lineage specification of multipotent progenitor cells is governed by a balance of lineage-
affiliated transcription factors, such as GATA1 and PU. 1, which regulate the choice between …

It has been almost a quarter century since it was first appreciated that a class of oncogenes
contained in rapidly transforming avian retroviruses encoded DNA-binding transcription …

Regulatory elements recruit transcription factors that modulate gene expression distinctly
across cell types, but the relationships among these remains elusive. To address this, we …