Deciphering how the regulatory DNA sequence of a gene dictates its expression in
response to intra and extracellular cues is one of the leading challenges in modern …

The genomic revolution has indubitably brought about a paradigm shift in the field of
molecular biology, wherein we can sequence, write and re-write genomes. In spite of …

We study stochastic phenomena for a model of bacterial infection and neutrophils defense.
Sufficient conditions of stochastic permanence and extinction for the random model are …

Transition or metastasis is a main characteristic of tumor developmental processes.
However, the mechanism behind the transition and what costs involved are obscure when …

The post-transcriptional regulation of a protein by multiple small RNA molecules has been
formulated as a stochastic process. An approximate solution of the master equation shows …

Regulation of transcription is a vital process in cells, but mechanistic details of this regulation
still remain elusive. The dominant approach to unravel the dynamics of transcriptional …

MicroRNAs bind to and regulate the abundance and activity of target messenger RNA
through sequestration, enhanced degradation, and suppression of translation. Although …

MicroRNAs are small noncoding RNAs that regulate genes post-transciptionally by binding
and degrading target eukaryotic mRNAs. We use a quantitative model to study gene …

In this paper we study an important global regulation mechanism of transcription of
biological cells using specific macro-molecules, 6S RNAs. The functional property of 6S …

Transcription is the dominant point of control of gene expression. Biochemical studies have
revealed key molecular components of transcription and their interactions, but the dynamics …