The tightly orchestrated temporal and spatial control of signal transducer and activator of
transcription 3 (STAT3) activity in epithelial, immune and stromal cells is critical for wound …

Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that
regulates various biological processes, including proliferation, metastasis, angiogenesis …

Acute myeloid leukemia (AML) is the most common acute leukemia in adults, with an
incidence of over 20 000 cases per year in the United States alone. Large chromosomal …

Signal transducer and activator of transcription 3 (STAT3) is a cytoplasmic transcription
factor that regulates cell proliferation, differentiation, apoptosis, angiogenesis, inflammation …

In patients with chronic kidney disease (CKD), loss of cellular proteins increases the risks of
morbidity and mortality. Persistence of muscle protein catabolism in CKD results in striking …

Cancer is a prevalent cause of mortality around the world. Aberrated activation of Janus
kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathway …

Acute myeloid leukemia (AML) is characterized by the presence of leukemia stem cells
(LSCs), and failure to fully eradicate this population contributes to disease …

The Janus kinase/signal transducer and activator of transcription (Jak/Stat) pathway was
discovered 20 years ago as a mediator of cytokine signaling. Since this time, more than …

We have developed a deep-scale proteome and phosphoproteome database from 44
representative acute myeloid leukemia (AML) patients from the LAML TCGA dataset and 6 …

Among the cytokines linked to inflammation-associated cancer, interleukin (IL)-6 drives
many of the cancer 'hallmarks' through downstream activation of the Janus kinase/signal …