The development of disease-modifying drugs and differential diagnostic agents is an urgent
medical need in Parkinson's disease. Despite the complex pathophysiological pathway, the …

Abstract Scientifically qualified LC–MS/MS methods are essential for the determination of
small molecule drug candidates and/or their metabolite (s) in support of various non …

Predictive performance assays are crucial for the development and approval of
nanomedicines and their bioequivalent successors. At present, there are no established …

Over the last decades, comprehensive two-dimensional gas chromatography (GC× GC) has
emerged as a significant separation tool for high-resolution analysis of disease-associated …

Background Recent efforts to repurpose existing drugs to different indications have been
accompanied by a number of computational methods, which incorporate protein-protein …

The anti-dermatophytic (Proteus vulgaris, Klebsiella pneumoniae, Enterobacter aerogenes,
Propionibacterium acnes, Staphylococcus aureus, and Streptococcus pyogenes) and …

Although liquid chromatography-tandem mass spectrometry is the gold standard analytical
platform for the quantification of drugs, metabolites, and biomarkers in biological samples, it …

The process of finding new drugs begins with the identification of a target and its validation,
then hits are found, leads are generated, and they are optimized. Eventually, a suitable and …

Targeting the transient receptor potential vanilloid 2 channels (TRPV2) in order to alleviate
or reverse the course of several diseases including multiple cancers, cardiovascular …

One of the biggest problems facing worldwide public health today is the human
immunodeficiency virus (HIV). In 2007 UNAIDS estimated that 33.2 million people were …