Erythropoiesis is a highly regulated process where sequential events ensure the proper
differentiation of hematopoietic stem cells into, ultimately, red blood cells (RBCs) …

The discovery of the molecular basis of sickle cell disease was an important landmark in
molecular medicine. The modern tools of molecular and cellular biology have refined our …

Mid-life stage adults are at higher risk of developing venous thrombosis
(VT)/thromboembolism (VT/E). Aging is characterized by an overproduction of reactive …

Sickle cell anaemia (SCA) is the consequence of abnormal haemoglobin production due to
an inherited point mutation in the β‐globin gene. The resulting haemoglobin tetramer is …

We have studied the membrane proteins of band 3 anion exchanger (AE1)–deficient mouse
and human red blood cells. It has been shown previously that proteins of the band 3 …

Sickle cell disease (SCD) is an inherited monogenic disorder and the most common severe
hemoglobinopathy in the world. SCD is characterized by a point mutation in the β-globin …

Red blood cell (RBC) blood group antigens are polymorphic, inherited, carbohydrate or
protein structures located on the extracellular surface of the RBC membrane. They …

Endothelial cell adhesion molecules orchestrate the recruitment and binding of inflammatory
cells to vascular endothelium. With endothelial dysfunction and vascular injury, the levels of …

Erythroblastic islands are specialized microenvironmental compartments within which
definitive mammalian erythroblasts proliferate and differentiate. These islands consist of a …

Haemostasis encompasses a set of strictly regulated actions, such as vasoconstriction,
platelet activation and blood coagulation. Endothelial cells play a crucial role in all of these …