Animal models to understand the etiology and pathophysiology of polycystic ovary syndrome

E Stener-Victorin, V Padmanabhan… - Endocrine …, 2020 - academic.oup.com
More than 1 out of 10 women worldwide are diagnosed with polycystic ovary syndrome
(PCOS), the leading cause of female reproductive and metabolic dysfunction. Despite its …

Key signalling pathways underlying the aetiology of polycystic ovary syndrome

KA Walters, A Moreno-Asso, NK Stepto… - Journal of …, 2022 - joe.bioscientifica.com
Polycystic ovary syndrome (PCOS) is a common endocrine condition characterised by a
range of reproductive, endocrine, metabolic and psychological abnormalities. Reports …

Androgen action in adipose tissue and the brain are key mediators in the development of PCOS traits in a mouse model

MJ Cox, MC Edwards, V Rodriguez Paris… - …, 2020 - academic.oup.com
Polycystic ovary syndrome (PCOS) is a complex disorder characterized by endocrine,
reproductive, and metabolic abnormalities. Despite PCOS being the most common …

[HTML][HTML] Androgen-induced insulin resistance is ameliorated by deletion of hepatic androgen receptor in females

S Andrisse, M Feng, Z Wang, O Awe, L Yu… - … : official publication of …, 2021 - ncbi.nlm.nih.gov
Androgen excess is one of the most common endocrine disorders of reproductive-aged
women, affecting up to 20% of this population. Women with elevated androgens often exhibit …

Androgen signaling in adipose tissue, but less likely skeletal muscle, mediates development of metabolic traits in a PCOS mouse model

T Xiong, V Rodriguez Paris… - American Journal …, 2022 - journals.physiology.org
Polycystic ovary syndrome (PCOS) is a common, multifactorial disorder characterized by
endocrine, reproductive, and metabolic dysfunction. As the etiology of PCOS is unknown …

Androgen inhibition of reproductive neuroendocrine function in females and transgender males

AS Kauffman - Endocrinology, 2024 - academic.oup.com
Ovarian function is controlled by pituitary secretion of luteinizing hormone (LH) and follicle
stimulating hormone (FSH), which in turn are governed by gonadotropin releasing hormone …

Reproductive Profile of Neuronal Androgen Receptor Knockout Female Mice With a Low Dose of DHT

V Ubba, S Joseph, O Awe, D Jones, MK Dsilva… - …, 2024 - academic.oup.com
Hyperandrogenism and polycystic ovarian syndrome result from the imbalance or increase
of androgen levels in females. Androgen receptor (AR) mediates the effects of androgens …

An improved time-and labor-efficient protocol for mouse primary hepatocyte isolation

M Feng, S Divall, S Wu - JoVE (Journal of Visualized Experiments), 2021 - jove.com
Primary hepatocytes are used extensively in liver in vitro research, especially in glucose
metabolism studies. A base technique has been adapted based on different needs, like time …

Comparison of reproductive function between normal and hyperandrogenemia conditions in female mice with deletion of hepatic androgen receptor

M Feng, S Divall, D Jones, V Ubba, X Fu… - Frontiers in …, 2022 - frontiersin.org
Obesity, altered glucose homeostasis, hyperinsulinism, and reproductive dysfunction
develops in female humans and mammals with hyperandrogenism. We previously reported …

Lower FSH with normal fertility in Male mice lacking gonadotroph kisspeptin receptor

Y Ma, O Awe, S Radovick, X Yang, S Divall… - Frontiers in …, 2022 - frontiersin.org
The kisspeptin receptor, crucial for hypothalamic control of puberty and reproduction, is also
present in the pituitary gland. Its role in the pituitary gland is not defined. Kisspeptin …