Guanylate cyclase C (GUCY2C) is a transmembrane receptor expressed on the luminal
aspect of the intestinal epithelium. Its ligands include bacterial heat-stable enterotoxins …

For years, guanylate cyclase seemed to be homogenic and tissue nonspecific enzyme;
however, in the last few years, in light of preclinical and clinical trials, it became an …

Background Cardiorenal syndrome is a major cause of mortality in patients with chronic
kidney disease (CKD). However, the involvement of detrimental humoral mediators in the …

Feeding intolerance (FI) is a common disease in preterm infants, often causing a delay in
individual development. Gut microbiota play an important role in nutrient absorption and …

Intestinal guanyl peptides like guanylin and uroguanylin are the potent regulators of fluid-ion
homeostasis. They are secreted from various cells of the intestinal mucosa, including …

Necrotizing enterocolitis (NEC) is a multifactorial gastrointestinal disease with high morbidity
and mortality among premature infants. This study aimed to identify novel methylation …

Abstract Background & Aims Disorders of gut‐brain interaction (DGBI) are complex
conditions that result in decreased quality of life and a significant cost burden. Linaclotide, a …

In the pig production cycle, the most delicate phase is weaning, a sudden and early change
that requires a quick adaptation, at the cost of developing inflammation and oxidation …

Objective: Activating mutations in the GUCY2C gene, which encodes the epithelial receptor
guanylate cyclase C, cause diarrhea due to increased loss of sodium chloride to the …

Ulcerative colitis (UC) is a major type of inflammatory bowel disease (IBD) and significantly
impacts patient quality of life. Previous research revealed that the guanylate cyclase-C (GC …