The guanylate cyclase C—cGMP signaling axis opposes intestinal epithelial injury and neoplasia
JA Rappaport, SA Waldman - Frontiers in oncology, 2018 - frontiersin.org
Guanylate cyclase C (GUCY2C) is a transmembrane receptor expressed on the luminal
aspect of the intestinal epithelium. Its ligands include bacterial heat-stable enterotoxins …
aspect of the intestinal epithelium. Its ligands include bacterial heat-stable enterotoxins …
Current modulation of guanylate cyclase pathway activity—mechanism and clinical implications
G Grześk, A Nowaczyk - Molecules, 2021 - mdpi.com
For years, guanylate cyclase seemed to be homogenic and tissue nonspecific enzyme;
however, in the last few years, in light of preclinical and clinical trials, it became an …
however, in the last few years, in light of preclinical and clinical trials, it became an …
The guanylate cyclase C agonist linaclotide ameliorates the gut–cardio–renal axis in an adenine-induced mouse model of chronic kidney disease
F Nanto-Hara, Y Kanemitsu, S Fukuda… - Nephrology Dialysis …, 2020 - academic.oup.com
Background Cardiorenal syndrome is a major cause of mortality in patients with chronic
kidney disease (CKD). However, the involvement of detrimental humoral mediators in the …
kidney disease (CKD). However, the involvement of detrimental humoral mediators in the …
Feeding intolerance alters the gut microbiota of preterm infants
Z Yuan, J Yan, H Wen, X Deng, X Li, S Su - PLoS One, 2019 - journals.plos.org
Feeding intolerance (FI) is a common disease in preterm infants, often causing a delay in
individual development. Gut microbiota play an important role in nutrient absorption and …
individual development. Gut microbiota play an important role in nutrient absorption and …
[PDF][PDF] Guanylin and uroguanylin: a promising nexus in intestinal electrolyte and fluid homeostasis.
S Samanta, AG Chaudhuri - Journal of Physiology & Pharmacology, 2021 - jpp.krakow.pl
Intestinal guanyl peptides like guanylin and uroguanylin are the potent regulators of fluid-ion
homeostasis. They are secreted from various cells of the intestinal mucosa, including …
homeostasis. They are secreted from various cells of the intestinal mucosa, including …
Epigenetic Insights Into Necrotizing Enterocolitis: Unraveling Methylation-Regulated Biomarkers
B Tian, X Xu, L Li, Y Tian, Y Liu, Y Mu, J Lu, K Song… - Inflammation, 2024 - Springer
Necrotizing enterocolitis (NEC) is a multifactorial gastrointestinal disease with high morbidity
and mortality among premature infants. This study aimed to identify novel methylation …
and mortality among premature infants. This study aimed to identify novel methylation …
Microbiota‐derived butyrate dampens linaclotide stimulation of the guanylate cyclase C pathway in patient‐derived colonoids
A Velez Lopez, A Waddell, S Antonacci… - …, 2023 - Wiley Online Library
Abstract Background & Aims Disorders of gut‐brain interaction (DGBI) are complex
conditions that result in decreased quality of life and a significant cost burden. Linaclotide, a …
conditions that result in decreased quality of life and a significant cost burden. Linaclotide, a …
A blend of selected botanicals maintains intestinal epithelial integrity and reduces susceptibility to Escherichia coli F4 infection by modulating acute and chronic …
A Bonetti, A Toschi, B Tugnoli, A Piva… - Frontiers in Veterinary …, 2023 - frontiersin.org
In the pig production cycle, the most delicate phase is weaning, a sudden and early change
that requires a quick adaptation, at the cost of developing inflammation and oxidation …
that requires a quick adaptation, at the cost of developing inflammation and oxidation …
Genetic and transcriptional analysis of inflammatory bowel disease-associated pathways in patients with GUCY2C-linked familial diarrhea
RR Tronstad, T Polushina, HR Brattbakk… - Scandinavian Journal …, 2018 - Taylor & Francis
Objective: Activating mutations in the GUCY2C gene, which encodes the epithelial receptor
guanylate cyclase C, cause diarrhea due to increased loss of sodium chloride to the …
guanylate cyclase C, cause diarrhea due to increased loss of sodium chloride to the …
The endogenous ligand for guanylate cyclase-C activation reliefs intestinal inflammation in the DSS colitis model
D Lan, Y Wen, X Dong, Q Yang, Y Liu… - Acta Biochimica …, 2020 - abp.ptbioch.edu.pl
Ulcerative colitis (UC) is a major type of inflammatory bowel disease (IBD) and significantly
impacts patient quality of life. Previous research revealed that the guanylate cyclase-C (GC …
impacts patient quality of life. Previous research revealed that the guanylate cyclase-C (GC …