Plasmodium falciparum malaria, an infectious disease caused by a parasitic protozoan,
claims the lives of nearly a million children each year in Africa alone and is a top public …

Our understanding of, and approach to, pulmonary arterial hypertension has undergone a
paradigm shift in the past decade. Once a condition thought to be dominated by increased …

The covalent marking of proteins by methyl group addition to arginine residues can promote
their recognition by binding partners or can modulate their biological activity. A small family …

Recent clinical and experimental studies are redefining the cellular and molecular bases of
pulmonary arterial hypertension (PAH). The genetic abnormalities first identified in …

Pulmonary arterial hypertension (PAH) is a syndrome in which pulmonary arterial
obstruction increases pulmonary vascular resistance, which leads to right ventricular (RV) …

Endothelial cells situated at the interface between blood and the vessel wall play a crucial
role in controlling vascular tone and homeostasis, particularly in determining the expression …

Nitric oxide production in response to flow-dependent shear forces applied on the surface of
endothelial cells is a fundamental mechanism of regulation of vascular tone, peripheral …

Background—Proton pump inhibitors (PPIs) are gastric acid–suppressing agents widely
prescribed for the treatment of gastroesophageal reflux disease. Recently, several studies in …

The overall production of nitric oxide (NO) is decreased in chronic kidney disease (CKD)
which contributes to cardiovascular events and further progression of kidney damage. There …

Background A growing number of studies linked elevated concentrations of circulating
asymmetric (ADMA) and symmetric (SDMA) dimethylarginine to mortality and cardiovascular …