[HTML][HTML] The clinical application of microRNAs in infectious disease

RE Drury, D O'Connor, AJ Pollard - Frontiers in immunology, 2017 - frontiersin.org
MicroRNAs (miRNAs) are short single-stranded non-coding RNA sequences that
posttranscriptionally regulate up to 60% of protein encoding genes. Evidence is emerging …

microRNAs in human brucellosis: a promising therapeutic approach and biomarker for diagnosis and treatment

S Kazemi, R Mirzaei, M Sholeh… - Immunity …, 2021 - Wiley Online Library
Introduction Human brucellosis is a zoonotic bacterial disease with up to 500,000 new cases
each year. The major evasion mechanisms from the host immune system by Brucella are …

[HTML][HTML] Brucella suppress STING expression via miR-24 to enhance infection

M Khan, JS Harms, Y Liu, J Eickhoff, JW Tan… - PLoS …, 2020 - journals.plos.org
Brucellosis, caused by a number of Brucella species, remains the most prevalent zoonotic
disease worldwide. Brucella establish chronic infections within host macrophages despite …

[HTML][HTML] Brucella-Induced Downregulation of lncRNA Gm28309 Triggers Macrophages Inflammatory Response Through the miR-3068-5p/NF-κB Pathway

X Deng, J Guo, Z Sun, L Liu, T Zhao, J Li… - Frontiers in …, 2020 - frontiersin.org
Objectives The underlying mechanism of the inflammatory response against Brucellosis
caused by Brucella remains poorly understood. This study aimed to determine the role of …

[HTML][HTML] Comprehensive Transcriptomic Comparison between Porcine CD8 and CD8+ Gamma Delta T Cells Revealed Distinct Immune Phenotype

S Kim, B Lim, SS Mattoo, EY Oh, CG Jeong, WI Kim… - Animals, 2021 - mdpi.com
Simple Summary This study was conducted to comprehensively understand the functional
mechanisms of CD8+/− porcine gamma delta (γδ) T cells related to the immune system …

[HTML][HTML] The microRNA expression signature of CD4+ T cells in the transition of brucellosis into chronicity

F Budak, SH Bal, G Tezcan, EH Akalın, A Yılmaz… - PLoS …, 2018 - journals.plos.org
Brucellosis is a serious infectious disease that continues to be a significant cause of
morbidity worldwide and across all ages. Despite early diagnosis and treatment, 10–30% of …

[HTML][HTML] System Biology Investigation Revealed Lipopolysaccharide and Alcohol-Induced Hepatocellular Carcinoma Resembled Hepatitis B Virus Immunobiology and …

VS Patil, DR Harish, GH Sampat, S Roy… - International Journal of …, 2023 - mdpi.com
Hepatitis B infection caused by the hepatitis B virus is a life-threatening cause of liver
fibrosis, cirrhosis, and hepatocellular carcinoma. Researchers have produced multiple in …

Roles of novel IL-1 family (IL-36, IL-37, and IL-38) members in chronic brucellosis

P Hiz, E Kanbur, N Demir, H Akalin, E Cagan… - Cytokine, 2020 - Elsevier
The secretion of interleukin (IL)-1 family cytokines is one of the most potent and earliest pro-
inflammatory responses triggered by brucellosis. However, the roles of the most recently …

Investigation of LncRNAs Expression as a Potential Biomarker in the Diagnosis and Treatment of Human Brucellosis

M Kodori, M Abavisani, H Fathizadeh… - Current …, 2024 - ingentaconnect.com
Long non-coding RNAs (LncRNAs) are significant contributors to bacterial infections and
host defense responses, presenting a novel class of gene regulators beyond conventional …

CD14 gene silencing alters the microRNA expression profile of RAW264.7 cells stimulated by Brucella melitensis infection

H Rong, H Jiao, Y Hao, F Pang, G Li, D Peng… - Innate …, 2017 - journals.sagepub.com
Innate recognition of Brucella spp. is a key step in the activation of inflammation. CD14 binds
PAMPs and is involved in LPS-induced pro-inFammatory cytokine release. Previously we …