Questions have been raised since the discovery of UBA6 and its significant coexistence with
UBE1 in the ubiquitin–proteasome system (UPS). The facts that UBA6 has the dedicated E2 …

The advancement of RNAseq and isoform-specific expression platforms has led to the
understanding that isoform changes can alter molecular signaling to promote tumorigenesis …

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease
characterized by the loss of upper and lower motor neurons, which eventually may lead to …

Background Sialic acids are widely distributed in animal tissues, and aberrantly expressed
in a variety of cancer types. High expression of sialic acid contributes to tumor …

Background Progressive supranuclear palsy (PSP) is a neurodegenerative disorder
clinically characterized by progressive postural instability, supranuclear gaze palsy …

Phenotype-based screening can identify small molecules that elicit a desired cellular
response, but additional approaches are required to characterize their targets and …

The targeting protein for Xenopus kinesin‐like protein 2 (TPX2) is associated with the
metastasis and prognosis of bladder cancer. p53 is closely related to the progression of …

The infant gut microbiome consists of a complex and diverse microbial community.
Comprehensive taxonomic and metabolic functional knowledge about microbial …

With the advent of the high-throughput technologies and exciting times for biology, the
discipline of analytical methodology is experiencing a surge in the growth and the scope …

Urothelial bladder cancer is a complex disease displaying a landscape of heterogenous
molecular subtypes, mutation profiles and clinical presentations. Diagnosis and surveillance …