Dysregulation of mRNA translation is a frequent feature of neoplasia. Many oncogenes and
tumour suppressors affect the translation machinery, making aberrant translation a …

▪ Abstract Eukaryotic translation initiation factor 4F (eIF4F) is a protein complex that mediates
recruitment of ribosomes to mRNA. This event is the rate-limiting step for translation under …

The 5′ mRNA cap structure is essential for efficient gene expression from yeast to human. It
plays a critical role in all aspects of the life cycle of an mRNA molecule. Capping occurs co …

The contribution of the mRNA cap-binding protein, eIF-4E, to malignant transformation and
progression has been illuminated over the past decade. eIF-4E overexpression has been …

Eukaryotic translation initiation factor 4E (eIF-4E), which possesses cap-binding activity,
functions in the recruitment of mRNA to polysomes as part of a three-subunit complex, eIF …

Abstract Treatment of mammalian cells with the immunosuppressant rapamycin, a bacterial
macrolide, selectively suppresses mitogen‐induced translation of an essential class of …

Increased cap-dependent mRNA translation rates are frequently observed in human
cancers. Mechanistically, many human tumors often overexpress the cap binding protein …

Translational control is a key step in eukaryotic gene expression. The majority of
translational control occurs at the level of initiation, thus implicating the 5′ untranslated …

The structure of m7GpppN (where N is any nucleotide), termed cap, is present at the 5'end of
all eukaryotic cellular mRNAs (except organellar). The eukaryotic initiation factor 4E (eIF-4E) …

Regulation of translation of mRNAs coding for specific proteins plays an important role in
controlling cell growth, differentiation, and transformation. Two proteins have been …