Mechanisms of ketamine action as an antidepressant
Clinical studies have demonstrated that a single sub-anesthetic dose of the dissociative
anesthetic ketamine induces rapid and sustained antidepressant actions. Although this …
anesthetic ketamine induces rapid and sustained antidepressant actions. Although this …
Tryptophan metabolism as a pharmacological target
M Modoux, N Rolhion, S Mani, H Sokol - Trends in pharmacological …, 2021 - cell.com
L-Tryptophan is an essential amino acid required for protein synthesis. It undergoes an
extensive and complex metabolism along several pathways, resulting in many bioactive …
extensive and complex metabolism along several pathways, resulting in many bioactive …
Prognosis and improved outcomes in major depression: a review
C Kraus, B Kadriu, R Lanzenberger… - Translational …, 2019 - nature.com
Abstract Treatment outcomes for major depressive disorder (MDD) need to be improved.
Presently, no clinically relevant tools have been established for stratifying subgroups or …
Presently, no clinically relevant tools have been established for stratifying subgroups or …
[HTML][HTML] NMDAR inhibition-independent antidepressant actions of ketamine metabolites
Major depressive disorder affects around 16 per cent of the world population at some point
in their lives. Despite the availability of numerous monoaminergic-based antidepressants …
in their lives. Despite the availability of numerous monoaminergic-based antidepressants …
Targeting glutamate signalling in depression: progress and prospects
Major depressive disorder (MDD) is severely disabling, and current treatments have limited
efficacy. The glutamate N-methyl-d-aspartate receptor (NMDAR) antagonist ketamine was …
efficacy. The glutamate N-methyl-d-aspartate receptor (NMDAR) antagonist ketamine was …
[HTML][HTML] Molecular mechanisms of the rapid-acting and long-lasting antidepressant actions of (R)-ketamine
K Hashimoto - Biochemical Pharmacology, 2020 - Elsevier
Ketamine, an anesthetic developed in the early 1960s, is also a popular abused drug
among young people at dance parties and raves and among spiritual seekers, because it …
among young people at dance parties and raves and among spiritual seekers, because it …
Neuroinflammation and the kynurenine pathway in CNS disease: molecular mechanisms and therapeutic implications
Diseases of the central nervous system (CNS) remain a significant health, social and
economic problem around the globe. The development of therapeutic strategies for CNS …
economic problem around the globe. The development of therapeutic strategies for CNS …
NMDA receptor activation-dependent antidepressant-relevant behavioral and synaptic actions of ketamine
Ketamine is a well-characterized NMDA receptor (NMDAR) antagonist, although the
relevance of this pharmacology to its rapid (within hours of administration) antidepressant …
relevance of this pharmacology to its rapid (within hours of administration) antidepressant …
Tryptophan metabolites along the microbiota-gut-brain axis: an interkingdom communication system influencing the gut in health and disease
A Bosi, D Banfi, M Bistoletti… - International Journal of …, 2020 - journals.sagepub.com
The 'microbiota-gut-brain axis' plays a fundamental role in maintaining host homeostasis,
and different immune, hormonal, and neuronal signals participate to this interkingdom …
and different immune, hormonal, and neuronal signals participate to this interkingdom …
Emerging treatment mechanisms for depression: focus on glutamate and synaptic plasticity
Highlights•Stress and depression are characterized by loss of synapses in prefrontal
cortex.•Rapid acting antidepressants increase synaptic contacts in prefrontal cortex.•NMDA …
cortex.•Rapid acting antidepressants increase synaptic contacts in prefrontal cortex.•NMDA …