Epigenetics of glioblastoma multiforme: From molecular mechanisms to therapeutic approaches

MS Uddin, A Al Mamun, BS Alghamdi, D Tewari… - Seminars in cancer …, 2022 - Elsevier
Glioblastoma multiforme (GBM) is the most common form of brain cancer and one of the
most aggressive cancers found in humans. Most of the signs and symptoms of GBM can be …

[HTML][HTML] Epithelial‑mesenchymal transition in glioblastoma progression

Y Iwadate - Oncology letters, 2016 - spandidos-publications.com
Epithelial‑mesenchymal transition (EMT) is a reversible biological process that occurs in
epithelial cells. EMT ultimately leads to the acquisition of a mesenchymal phenotype …

Radioresistance in Glioblastoma and the Development of Radiosensitizers

MY Ali, CR Oliva, ASM Noman, BG Allen, PC Goswami… - Cancers, 2020 - mdpi.com
Simple Summary Numerous mechanisms of glioblastoma (GBM) radioresistance have been
identified but have not yet resulted in development of effective radiosensitizer that can …

[HTML][HTML] WNT signaling in glioblastoma and therapeutic opportunities

Y Lee, JK Lee, SH Ahn, J Lee, DH Nam - Laboratory investigation, 2016 - Elsevier
WNTs and their downstream effectors regulate proliferation, death, and migration and cell
fate decision. Deregulation of WNT signaling is associated with various cancers including …

[HTML][HTML] Interplay between microRNAs and WNT/β-catenin signalling pathway regulates epithelial–mesenchymal transition in cancer

NM Ghahhari, S Babashah - European journal of cancer, 2015 - Elsevier
The WNT/β-catenin signalling implies its significance in maintaining an epithelial cell
phenotype, proper cell–cell junctions, and tissue homeostasis. Dysregulation of the …

The epithelial‐to‐mesenchymal transition‐like process in glioblastoma: an updated systematic review and in silico investigation

IC Iser, MB Pereira, G Lenz… - Medicinal Research …, 2017 - Wiley Online Library
Glioblastoma multiforme (GBM) is the most aggressive form of brain cancer due to its highly
invasive nature that impedes the surgical removal of all tumor cells, making relapse …

Targeting the Wnt pathway in human cancers: therapeutic targeting with a focus on OMP-54F28

PN Le, JD McDermott, A Jimeno - Pharmacology & therapeutics, 2015 - Elsevier
The Wnt signaling pathways are a group of signal transduction pathways that play an
important role in cell fate specification, cell proliferation and cell migration. Aberrant …

A systematic review of microRNA in glioblastoma multiforme: micro-modulators in the mesenchymal mode of migration and invasion

HG Møller, AP Rasmussen, HH Andersen… - Molecular …, 2013 - Springer
Glioblastoma multiforme (GBM) is an incurable form of brain cancer with a very poor
prognosis. Because of its highly invasive nature, it is impossible to remove all tumor cells …

MicroRNA-218 Inhibits Glioma Invasion, Migration, Proliferation, and Cancer Stem-like Cell Self-Renewal by Targeting the Polycomb Group Gene Bmi1

Y Tu, X Gao, G Li, H Fu, D Cui, H Liu, W Jin, Y Zhang - Cancer research, 2013 - AACR
Malignant gliomas are the most common central nervous system tumors and the molecular
mechanism driving their development and recurrence is still largely unknown, limiting the …

Epithelial-to-mesenchymal (-like) transition as a relevant molecular event in malignant gliomas

UD Kahlert, G Nikkhah, J Maciaczyk - Cancer letters, 2013 - Elsevier
Tumor dissemination and metastatic behavior account for the vast majority of cancer
associated mortality. Epithelial tumors achieve this progressive state via epithelial-to …