A substantial and diverse body of literature suggests that the pathophysiology of
schizophrenia is related to deficits of bioenergetic function. While antipsychotics are an …

Though the pathophysiology of schizophrenia remains poorly understood, altered brain
energy metabolism is increasingly implicated. Here, we conduct meta-analyses of the …

Postmortem studies reveal that the brain pH in schizophrenia patients is lower than normal.
The exact cause of this low pH is unclear, but increased lactate levels due to abnormal …

In search of interventions targeting brain dysfunction and underlying cognitive impairment in
schizophrenia, we look at the brain and beyond to the potential role of dysfunctional …

Mitochondria are cellular organelles essential for energy metabolism and antioxidant
defense. Mitochondrial impairment is implicated in many psychiatric disorders, including …

More and more evidence shows how brain energy metabolism is the linkage between
physiological and morphological synaptic plasticity and memory consolidation. Different …

These results support that ketogenic diet may present a novel therapeutic approach through
restoring brain energy metabolism in schizophrenia. Randomized controlled clinical trials …

Proton magnetic resonance spectroscopy (MRS) studies in schizophrenia have shown
altered GABAergic, glutamatergic, and bioenergetic pathways, but if these abnormalities are …

Schizophrenia (SCZ) is a severe neurodevelopmental disorder affecting 1% of populations
worldwide with a grave disability and socioeconomic burden. Current antipsychotic …

Regulation of neuronal metabolism during early brain development is crucial for directing
synaptic plasticity and proper circuit formation. Alterations in neuronal glycolysis or …