Opening doors with ultrasound and microbubbles: Beating biological barriers to promote drug delivery

J Deprez, G Lajoinie, Y Engelen, SC De Smedt… - Advanced drug delivery …, 2021 - Elsevier
Apart from its clinical use in imaging, ultrasound has been thoroughly investigated as a tool
to enhance drug delivery in a wide variety of applications. Therapeutic ultrasound, as such …

Understanding ultrasound induced sonoporation: definitions and underlying mechanisms

I Lentacker, I De Cock, R Deckers, SC De Smedt… - Advanced drug delivery …, 2014 - Elsevier
In the past two decades, research has underlined the potential of ultrasound and
microbubbles to enhance drug delivery. However, there is less consensus on the …

The role of ultrasound-driven microbubble dynamics in drug delivery: from microbubble fundamentals to clinical translation

S Roovers, T Segers, G Lajoinie, J Deprez, M Versluis… - Langmuir, 2019 - ACS Publications
In the last couple of decades, ultrasound-driven microbubbles have proven excellent
candidates for local drug delivery applications. Besides being useful drug carriers …

Ultrasound-mediated tumor imaging and nanotherapy using drug loaded, block copolymer stabilized perfluorocarbon nanoemulsions

N Rapoport, KH Nam, R Gupta, Z Gao, P Mohan… - Journal of Controlled …, 2011 - Elsevier
Perfluorocarbon nanoemulsions can deliver lipophilic therapeutic agents to solid tumors and
simultaneously provide for monitoring nanocarrier biodistribution via ultrasonography and/or …

Ultrasound and microbubble mediated drug delivery: acoustic pressure as determinant for uptake via membrane pores or endocytosis

I De Cock, E Zagato, K Braeckmans, Y Luan… - Journal of controlled …, 2015 - Elsevier
Although promising results are achieved in ultrasound mediated drug delivery, its underlying
biophysical mechanisms remain to be elucidated. Pore formation as well as endocytosis has …

A concise review on cancer treatment methods and delivery systems

E Bidram, Y Esmaeili, H Ranji-Burachaloo… - Journal of Drug Delivery …, 2019 - Elsevier
The ultimate purpose of current cancer research is to develop a comprehensive treatment for
cancer. Recent studies have shown an increased interest in investigating the capacity of …

Cardiovascular drug delivery with ultrasound and microbubbles

E Unger, T Porter, J Lindner, P Grayburn - Advanced drug delivery reviews, 2014 - Elsevier
Microbubbles lower the threshold for cavitation of ultrasound and have multiple potential
therapeutic applications in the cardiovascular system. One of the first therapeutic …

Nanobubbles: a promising efficient tool for therapeutic delivery

R Cavalli, M Soster, M Argenziano - Therapeutic delivery, 2016 - Taylor & Francis
In recent decades ultrasound-guided delivery of drugs loaded on nanocarriers has been the
focus of increasing attention to improve therapeutic treatments. Ultrasound has often been …

Microbubbles as ultrasound contrast agents for molecular imaging: preparation and application

S Unnikrishnan, AL Klibanov - American journal of …, 2012 - Am Roentgen Ray Soc
OBJECTIVE. The purpose of this review is to describe trends in microbubble application in
molecular imaging. CONCLUSION. Microbubbles are used for contrast ultrasound imaging …

Current advances in ultrasound-combined nanobubbles for cancer-targeted therapy: a review of the current status and future perspectives

C Su, XJ Ren, F Nie, T Li, W Lv, H Li, Y Zhang - RSC advances, 2021 - pubs.rsc.org
The non-specific distribution, non-selectivity towards cancerous cells, and adverse off-target
side effects of anticancer drugs and other therapeutic molecules lead to their inferior clinical …