AlphaFold predictions of fold-switched conformations are driven by structure memorization
Recent work suggests that AlphaFold (AF)–a deep learning-based model that can
accurately infer protein structure from sequence–may discern important features of folded …
accurately infer protein structure from sequence–may discern important features of folded …
[HTML][HTML] Proteins with alternative folds reveal blind spots in AlphaFold-based protein structure prediction
Highlights•AlphaFold-based methods often predict single protein structures with high
accuracy.•However, these methods sometimes fail to predict alternative …
accuracy.•However, these methods sometimes fail to predict alternative …
SSDraw: software for generating comparative protein secondary structure diagrams
The program SSDraw generates publication‐quality protein secondary structure diagrams
from three‐dimensional protein structures. To depict relationships between secondary …
from three‐dimensional protein structures. To depict relationships between secondary …
[HTML][HTML] AlphaFold2 has more to learn about protein energy landscapes
Recent work suggests that AlphaFold2 (AF2)–a deep learning-based model that can
accurately infer protein structure from sequence–may discern important features of folded …
accurately infer protein structure from sequence–may discern important features of folded …
Dissecting the Puzzling Roles of FAM46C: A Multifaceted Pan-Cancer Tumour Suppressor with Increasing Clinical Relevance
G Lai, F De Grossi, I Catusi, E Pesce, N Manfrini - Cancers, 2024 - mdpi.com
Simple Summary FAM46C is a tumour suppressor protein originally characterized in
multiple myeloma. Recent findings, however, suggest a much broader involvement of …
multiple myeloma. Recent findings, however, suggest a much broader involvement of …
TENT5A mediates the cancer-inhibiting effects of EGR1 by suppressing the protein stability of RPL35 in hepatocellular carcinoma
X Min, F Lin, X Zhao, J Yu, C Ge, S Zhang, X Li… - Cellular Oncology, 2024 - Springer
Purpose Terminal nucleotidyltransferase 5A (TENT5A), recently predicted as a non-
canonical poly (A) polymerase, is critically involved in several human disorders including …
canonical poly (A) polymerase, is critically involved in several human disorders including …
[HTML][HTML] 1p 缺失在多发性骨髓瘤中的研究进展
郭沙， 龚珊， 张瑞， 曲建华 - Advances in Clinical Medicine, 2023 - hanspub.org
多发性骨髓瘤(MM) 是终末分化的B 细胞恶性肿瘤, 被广泛认为是无法治愈的,
因为许多患者要么产生了耐药性, 要么最终复发. 为了制定精确有效的治疗策略 …
因为许多患者要么产生了耐药性, 要么最终复发. 为了制定精确有效的治疗策略 …
A resource for comparing AF-Cluster and other AlphaFold2 sampling methods
We are excited that Porter et al. have explored [1-3] the AF-Cluster [4] algorithm-this is
critical for the field to advance. Increasingly many methods have been reported for …
critical for the field to advance. Increasingly many methods have been reported for …