Metastasis remains a pivotal characteristic of cancer and is the primary contributor to cancer-
associated mortality. Despite its significance, the mechanisms governing metastasis are not …

Compared with traditional therapies, targeted therapy has merits in selectivity, efficacy, and
tolerability. Small molecule inhibitors are one of the primary targeted therapies for cancer …

The success of precision oncology—which aims to match the right therapies to the right
patients based on molecular status—is predicated on a robust pipeline of molecular targets …

The proper transfer of genetic information from DNA to RNA to protein is essential for cell-
fate control, development, and health. Methylation of DNA, RNAs, histones, and non-histone …

Translating genome-wide association study (GWAS) loci into causal variants and genes
requires accurate cell-type-specific enhancer–gene maps from disease-relevant tissues …

A growing body of evidence indicates an important role of miRNAs in cancer; however, there
is no definitive, convenient-to-use list of cancer-related miRNAs or miRNA genes that may …

Lung cancer is a lethal malignancy lacking effective therapies. Emerging evidence suggests
that epigenetic enzyme mutations are closely related to the malignant phenotype of lung …

Cancer continues to be a major global health challenge, accounting for 10 million deaths
annually worldwide. Since the inception of genome-wide cancer sequencing studies 20 …

In the decades following the discovery that genes encode proteins, scientists have tried to
exhaustively and comprehensively characterize the human genome. Recent advances in …

Cancer constitutes a multifaceted ailment characterized by the dysregulation of numerous
genes and pathways. Among these, LIM domain only 7 (LMO7) has emerged as a significant …