In trypanosomes, RNA polymerase II transcription is polycistronic and individual mRNAs are
excised by trans-splicing and polyadenylation. The lack of individual gene transcription …

The human pathogenic trypanosomatid species collectively called the “TriTryp parasites”–
Trypanosoma brucei, Trypanosoma cruzi and Leishmania spp.–have complex life cycles …

Differentiation is a central aspect of the parasite life cycle and encompasses adaptation to
both host and environment. If we accept that evolution cannot anticipate an organism's …

African trypanosomes are mainly transmitted by tsetse flies. In recent years there has been
good progress in understanding how the parasites prepare for transmission, detect their …

African trypanosomes cause sleeping sickness in humans and nagana in cattle. These
unicellular parasites are transmitted by the bloodsucking tsetse fly. In the mammalian host's …

Developmental regulation of mitochondrial uridine insertion/deletion editing in Trypanosoma
brucei is necessary to modulate parasite metabolism as it shifts from dependence on …

Abstract ZC3H20 and ZC3H21 are related trypanosome proteins with two C (x) 8C (x) 5C (x)
3H zinc finger motifs. ZC3H20 is present at a low level in replicating mammalian‐infective …

Many symbionts supplement their host's diet with essential nutrients. However, whether
these nutrients also enhance parasitism is unknown. In this study, we investigated whether …

Stress granules (SGs) are stress-induced RNA condensates consisting of stalled initiation
complexes resulting from translational inhibition. The biochemical composition and function …

Trypanosoma brucei is a species of unicellular parasite that can cause severe diseases in
livestock and humans, including African trypanosomiasis and Chagas disease. Adaptation …