P2X7 interactions and signaling–making head or tail of it
R Kopp, A Krautloher, A Ramírez-Fernández… - Frontiers in Molecular …, 2019 - frontiersin.org
Extracellular adenine nucleotides play important roles in cell–cell communication and tissue
homeostasis. High concentrations of extracellular ATP released by dying cells are sensed …
homeostasis. High concentrations of extracellular ATP released by dying cells are sensed …
The P2X7 receptor channel: recent developments and the use of P2X7 antagonists in models of disease
The P2X7 receptor is a trimeric ATP-gated cation channel found predominantly, but not
exclusively, on immune cells. P2X7 activation results in a number of downstream events …
exclusively, on immune cells. P2X7 activation results in a number of downstream events …
P2X7 in cancer: from molecular mechanisms to therapeutics
R Lara, E Adinolfi, CA Harwood, M Philpott… - Frontiers in …, 2020 - frontiersin.org
P2X7 is a transmembrane receptor expressed in multiple cell types including neurons,
dendritic cells, macrophages, monocytes, B and T cells where it can drive a wide range of …
dendritic cells, macrophages, monocytes, B and T cells where it can drive a wide range of …
Microglia in Alzheimer's disease: Pathogenesis, mechanisms, and therapeutic potentials
J Miao, H Ma, Y Yang, Y Liao, C Lin, J Zheng… - Frontiers in aging …, 2023 - frontiersin.org
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by protein
aggregation in the brain. Recent studies have revealed the critical role of microglia in AD …
aggregation in the brain. Recent studies have revealed the critical role of microglia in AD …
The P2X7 receptor
R Sluyter - Protein Reviews: Volume 19, 2017 - Springer
The P2X7 receptor is a trimeric ion channel gated by extracellular adenosine 5′-
triphosphate. The receptor is present on an increasing number of different cells types …
triphosphate. The receptor is present on an increasing number of different cells types …
ATP promotes the fast migration of dendritic cells through the activity of pannexin 1 channels and P2X7 receptors
PJ Sáez, P Vargas, KF Shoji, PA Harcha… - Science …, 2017 - science.org
Upon its release from injured cells, such as infected, transformed, inflamed, or necrotic cells,
extracellular adenosine-5ʹ-triphosphate (ATP) acts as a danger signal that recruits …
extracellular adenosine-5ʹ-triphosphate (ATP) acts as a danger signal that recruits …
Molecular and functional properties of P2X receptors—recent progress and persisting challenges
K Kaczmarek-Hájek, É Lörinczi, R Hausmann… - Purinergic …, 2012 - Springer
Abstract ATP-gated P2X receptors are trimeric ion channels that assemble as homo-or
heteromers from seven cloned subunits. Transcripts and/or proteins of P2X subunits have …
heteromers from seven cloned subunits. Transcripts and/or proteins of P2X subunits have …
ATP modifies the proteome of extracellular vesicles released by microglia and influences their action on astrocytes
F Drago, M Lombardi, I Prada, M Gabrielli… - Frontiers in …, 2017 - frontiersin.org
Extracellular ATP is among molecules promoting microglia activation and inducing the
release of extracellular vesicles (EVs), which are potent mediators of intercellular …
release of extracellular vesicles (EVs), which are potent mediators of intercellular …
The P2X7 Receptor in Microglial Cells Modulates the Endolysosomal Axis, Autophagy, and Phagocytosis
KE Campagno, CH Mitchell - Frontiers in cellular neuroscience, 2021 - frontiersin.org
Microglial cells regulate neural homeostasis by coordinating both immune responses and
clearance of debris, and the P2X7 receptor for extracellular ATP plays a central role in both …
clearance of debris, and the P2X7 receptor for extracellular ATP plays a central role in both …
The human P2X7 receptor and its role in innate immunity
The human P2X7 receptor is a two‐transmembrane ionotropic receptor which has a
ubiquitous distribution and is most highly expressed on immune cells. In macrophages and …
ubiquitous distribution and is most highly expressed on immune cells. In macrophages and …