Abstract Purpose of Review Postmenopausal osteoporosis reduces circulating estrogen
levels, which leads to osteoclast resorption, bone loss, and fracture. This review addresses …

Fracture is a common traumatic injury that is mostly caused by traffic accidents, falls, and
falls from height. Fracture healing is a long-term and complex process, and the mode of …

Clearance of senescent cells (SnCs) can prevent several age-related pathologies, including
bone loss. However, the local versus systemic roles of SnCs in mediating tissue dysfunction …

Mechanical environment has a crucial role in our organism at the different levels, ranging
from cells to tissues and our own organs. This regulatory role is especially relevant for …

During evolution, the development of bone was critical for many species to thrive and
function in the boundary conditions of Earth. Furthermore, bone also became a storehouse …

The bone-periodontal ligament-tooth (BPT) complex is a unique mechanosensing soft-/hard-
tissue interface, which governs the most rapid bony homeostasis in the body responding to …

Osteocyte network architecture is closely associated with bone turnover. The cellular
mechanosensing system regulates osteocyte dendrite formation by enhancing focal …

Bone homeostasis is a dynamic equilibrium between bone-forming osteoblasts and bone-
resorbing osteoclasts. This process is primarily controlled by the most abundant and …

During bone remodeling, osteoblasts are known to deposit unmineralized collagenous
tissue (osteoid), which mineralizes after some time lag. Some of the osteoblasts differentiate …

During crucial growth stages of vertebrate long bones, calcified cartilage beneath the growth
plate is anchored to bone by a third mineralized component, the cement line. Proper skeletal …