Resistance that stacks up: engineering rust and mildew disease control in the cereal crops wheat and barley

PM Dracatos, J Lu, J Sánchez‐Martín… - Plant biotechnology …, 2023 - Wiley Online Library
Staying ahead of the arms race against rust and mildew diseases in cereal crops is essential
to maintain and preserve food security. The methodological challenges associated with …

[HTML][HTML] Seeing is believing: Exploiting advances in structural biology to understand and engineer plant immunity

MA Outram, M Figueroa, J Sperschneider… - Current Opinion in Plant …, 2022 - Elsevier
Filamentous plant pathogens cause disease in numerous economically important crops.
These pathogens secrete virulence proteins, termed effectors, that modulate host cellular …

[HTML][HTML] A wheat resistosome defines common principles of immune receptor channels

A Förderer, E Li, AW Lawson, Y Deng, Y Sun… - Nature, 2022 - nature.com
Plant intracellular nucleotide-binding leucine-rich repeat receptors (NLRs) detect pathogen
effectors to trigger immune responses. Indirect recognition of a pathogen effector by the …

[HTML][HTML] Prediction of effector protein structures from fungal phytopathogens enables evolutionary analyses

K Seong, KV Krasileva - Nature Microbiology, 2023 - nature.com
Elucidating the similarity and diversity of pathogen effectors is critical to understand their
evolution across fungal phytopathogens. However, rapid divergence that diminishes …

Altering specificity and autoactivity of plant immune receptors Sr33 and Sr50 via a rational engineering approach

J Tamborski, K Seong, F Liu… - Molecular Plant …, 2023 - Am Phytopath Society
Many resistance genes deployed against pathogens in crops are intracellular nucleotide-
binding (NB) leucine-rich repeat (LRR) receptors (NLRs). The ability to rationally engineer …

Structural polymorphisms within a common powdery mildew effector scaffold as a driver of coevolution with cereal immune receptors

Y Cao, F Kümmel, E Logemann… - Proceedings of the …, 2023 - National Acad Sciences
In plants, host–pathogen coevolution often manifests in reciprocal, adaptive genetic
changes through variations in host nucleotide-binding leucine-rich repeat immune receptors …

[HTML][HTML] Pathways to engineering plant intracellular NLR immune receptors

R Zdrzałek, C Stone, JC De la Concepcion… - Current Opinion in Plant …, 2023 - Elsevier
Factors including climate change and increased global exchange are set to escalate the
prevalence of plant diseases, posing an unprecedented threat to global food security and …

Direct recognition of pathogen effectors by plant NLR immune receptors and downstream signalling

J Chen, X Zhang, JP Rathjen… - Essays in biochemistry, 2022 - portlandpress.com
Plants deploy extracellular and intracellular immune receptors to sense and restrict
pathogen attacks. Rapidly evolving pathogen effectors play crucial roles in suppressing …

[HTML][HTML] Barley MLA3 recognizes the host-specificity effector Pwl2 from Magnaporthe oryzae

HJ Brabham, D Gómez De La Cruz, V Were… - The Plant …, 2024 - academic.oup.com
Plant nucleotide-binding leucine-rich repeat (NLRs) immune receptors directly or indirectly
recognize pathogen-secreted effector molecules to initiate plant defense. Recognition of …

[HTML][HTML] The structural repertoire of Fusarium oxysporum f. sp. lycopersici effectors revealed by experimental and computational studies

SY Daniel, MA Outram, A Smith, CL McCombe… - elife, 2024 - elifesciences.org
Plant pathogens secrete proteins, known as effectors, that function in the apoplast or inside
plant cells to promote virulence. Effector recognition by cell-surface or cytosolic receptors …