Carbon Monoxide Poisoning: From Microbes to Therapeutics
Carbon monoxide (CO) poisoning leads to 50,000–100,000 emergency room visits and
1,500–2,000 deaths each year in the United States alone. Even with treatment, survivors …
1,500–2,000 deaths each year in the United States alone. Even with treatment, survivors …
Photoacoustic Calorimetry Studies of O2-Sensing FixL and (R200, I209) Variants from Sinorhizobium meliloti Reveal Conformational Changes Coupled to Ligand …
A Mokdad, ET Ang, M Desciak, C Ott, A Vilbert… - Biochemistry, 2023 - ACS Publications
FixL is an oxygen-sensing heme-PAS protein that regulates nitrogen fixation in the root
nodules of plants. In this paper, we present the first photothermal studies of the full-length …
nodules of plants. In this paper, we present the first photothermal studies of the full-length …
Developing a novel heme biosensor to produce high-active hemoproteins in Pichia pastoris through comparative transcriptomics
The development of a heme-responsive biosensor for dynamic pathway regulation in
eukaryotes has never been reported, posing a challenge for achieving the efficient synthesis …
eukaryotes has never been reported, posing a challenge for achieving the efficient synthesis …
[PDF][PDF] Characterization of a MHYT domain-coupled transcriptional regulator that responds to carbon monoxide
G Durante-Rodríguez… - Nucleic Acids …, 2024 - academic.oup.com
The MHYT domain, identified over two decades ago for its potential to detect diatomic gases
like CO, O2 or NO, has awaited experimental validation as a protein sensory domain. Here …
like CO, O2 or NO, has awaited experimental validation as a protein sensory domain. Here …
[HTML][HTML] Gas tunnel engineering of prolyl hydroxylase reprograms hypoxia signaling in cells
P Windsor, H Ouyang, JAG da Costa, AR Damodaran… - BioRxiv, 2023 - ncbi.nlm.nih.gov
Cells have evolved intricate mechanisms for recognizing and responding to changes in
oxygen (O 2) concentrations. Here, we have reprogrammed cellular hypoxia (low O 2) …
oxygen (O 2) concentrations. Here, we have reprogrammed cellular hypoxia (low O 2) …
Membrane-Bound Redox Enzyme Cytochrome bd-I Promotes Carbon Monoxide-Resistant Escherichia coli Growth and Respiration
MR Nastasi, VB Borisov, E Forte - International Journal of Molecular …, 2024 - mdpi.com
The terminal oxidases of bacterial aerobic respiratory chains are redox-active electrogenic
enzymes that catalyze the four-electron reduction of O2 to 2H2O taking out electrons from …
enzymes that catalyze the four-electron reduction of O2 to 2H2O taking out electrons from …
Quaternary Structure and DNA Binding Properties of the Heme-Dependent, CO-Sensing Transcriptional Regulator PxRcoM
MR Dent, MG Roberts, HE Bowman… - Studies of Microbial …, 2023 - search.proquest.com
A diverse array of microorganisms found in oceans, soils, and freshwater environments
utilize carbon monoxide (CO) as a source of energy and/or carbon. 1, 2 To regulate …
utilize carbon monoxide (CO) as a source of energy and/or carbon. 1, 2 To regulate …