The fibroblast growth factor (FGF) family is composed of 18 secreted signaling proteins
consisting of canonical FGFs and endocrine FGFs that activate four receptor tyrosine …

Aniridia, a rare congenital disease, is often characterized by a progressive, pronounced
limbal insufficiency and ocular surface pathology termed aniridia-associated keratopathy …

Organoids generated from pluripotent stem cells are used in the development of organ
replacement regenerative therapy by recapitulating the process of organogenesis. These …

The lacrimal gland is of central interest in ophthalmology both as the source of the aqueous
component of tear fluid and as the site of autoimmune pathology in the context of Sjogren's …

The incorporation of vasculature is known to be effective in tissue or organ functional
regeneration. However, a vague understanding of the interaction between epidermal …

Fluid secretion by exocrine glandular organs is essential to the survival of mammals. Each
glandular unit within the body is uniquely organized to carry out its own specific functions …

The lacrimal glands produce the aqueous component of the pre-ocular tear film, which is
essential for ocular health and optimal vision. This review explores its history, current …

Tissue engineering (TE) is a multidisciplinary research field aiming at the regeneration,
restoration, or replacement of damaged tissues and organs. Classical TE approaches …

Dry eye disease (DED) is a common multifactorial disease of the tear film and the ocular
surface. The problem of DED has gained attention globally, with millions of people affected …

A central question in development biology is how a limited set of signalling pathways can
instruct unlimited diversity of multicellular organisms. In this review, we use three ocular …