Extracellular matrix proteins play crucial roles in the formation of mineralized tissues like
bone and teeth via multifunctional mechanisms. In tooth enamel, ameloblastin (Ambn) is one …

While many effectors have been identified in enamel matrix and cells via genetic studies,
physiological networks underlying their expression levels and thus the natural spectrum of …

Tooth enamel forms in an ephemeral protein matrix where changes in protein abundance,
composition and posttranslational modifications are critical to achieve healthy enamel …

Highly specialized enamel matrix proteins (EMPs) are predominantly expressed in
odontogenic tissues and diverged from common ancestral gene. They are crucial for the …

Amelogenins are the most abundant protein species in forming dental enamel, taken to
regulate crystal shape and crystal growth. Unprotonated amelogenins can bind protons …

Ameloblasts are ectoderm-derived cells that produce an extracellular enamel matrix that
mineralizes to form enamel. The development and use of immortalized cell lines, with a …

Many studies have been conducted to elucidate the role of Type VI collagen in muscle and
tendon, however, its role in oral tissues remains unclear. In this study, an α2 (VI) deficient …

The enamel matrix protein Ameloblastin (Ambn) has critical physiological functions,
including regulation of mineral formation, cell differentiation, and cell–matrix adhesion. We …

Objective A 37-residue amino acid sequence corresponding to the segment encoded by
exon-5 of murine ameloblastin (Ambn), AB2 (Y67-Q103), has been implicated with …

The muscle segment homeogenes Msx1 and Msx2 play a major role in tooth and bone
formation. Periodontal osteoclast impairment also occurs in Msx2 null mutant mice, which is …