Structure and therapeutic uses of butyrylcholinesterase: application in detoxification, Alzheimer's disease, and fat metabolism
S Xing, Q Li, B Xiong, Y Chen, F Feng… - Medicinal Research …, 2021 - Wiley Online Library
Structural information of butyrylcholinesterase (BChE) and its variants associated with
several diseases are discussed here. Pure human BChE has been proved safe and effective …
several diseases are discussed here. Pure human BChE has been proved safe and effective …
Organophosphorus poisoning: Acute respiratory distress syndrome (ARDS) and cardiac failure as cause of death in hospitalized patients
GP Ramadori - International Journal of Molecular Sciences, 2023 - mdpi.com
Industrial production of food for animals and humans needs increasing amounts of
pesticides, especially of organophosphates, which are now easily available worldwide …
pesticides, especially of organophosphates, which are now easily available worldwide …
Toxicology of organophosphorus compounds in view of an increasing terrorist threat
F Worek, T Wille, M Koller, H Thiermann - Archives of toxicology, 2016 - Springer
The implementation of the Chemical Weapon Convention (CWC), prohibiting the
development, production, storage and use of chemical weapons by 192 nations and the ban …
development, production, storage and use of chemical weapons by 192 nations and the ban …
A-series agent A-234: initial in vitro and in vivo characterization
M Hrabinova, J Pejchal, V Hepnarova, L Muckova… - Archives of …, 2024 - Springer
A-series agent A-234 belongs to a new generation of nerve agents. The poisoning of a
former Russian spy Sergei Skripal and his daughter in Salisbury, England, in March 2018 …
former Russian spy Sergei Skripal and his daughter in Salisbury, England, in March 2018 …
High-throughput optical assays for sensing serine hydrolases in living systems and their applications
Q Jin, LL Song, LL Ding, J Zhang, DD Wang… - TrAC Trends in …, 2022 - Elsevier
Serine hydrolases (SHs) comprise a large family of hydrolytic enzymes that play crucial roles
in numerous physiological and pathological processes, such as blood coagulation, cancer …
in numerous physiological and pathological processes, such as blood coagulation, cancer …
[HTML][HTML] Novel 6-alkyl-bridged 4-arylalkylpiperazin-1-yl derivatives of azepino [4, 3-b] indol-1 (2H)-one as potent BChE-selective inhibitors showing protective effects …
F Samarelli, R Purgatorio, G Lopopolo… - European Journal of …, 2024 - Elsevier
Due to the putative role of butyrylcholinesterase (BChE) in regulation of acetylcholine levels
and functions in the late stages of the Alzheimer's disease (AD), the potential of selective …
and functions in the late stages of the Alzheimer's disease (AD), the potential of selective …
Highly selective NIR fluorescent probe for acetylcholinesterase and its application in pesticide residues detection
S He, S Zhang, X Zhao, X Zhu, L Chen, J Cui - Chinese Chemical Letters, 2022 - Elsevier
A series of near-infrared (NIR) fluorescent substrates (NDRO-1∼ 8) derived from
fluorophore NDRH with different volumes of ester bond as the recognition group were …
fluorophore NDRH with different volumes of ester bond as the recognition group were …
Exploiting butyrylcholinesterase inhibitors through a combined 3-D pharmacophore modeling, QSAR, molecular docking, and molecular dynamics investigation
S Kumar, A Manoharan, J Jayalakshmi… - RSC …, 2023 - pubs.rsc.org
Alzheimer's disease (AD), a neurodegenerative condition associated with ageing, can occur.
AD gradually impairs memory and cognitive function, which leads to abnormal behavior …
AD gradually impairs memory and cognitive function, which leads to abnormal behavior …
Investigating 1, 2, 3, 4, 5, 6-hexahydroazepino [4, 3-b] indole as scaffold of butyrylcholinesterase-selective inhibitors with additional neuroprotective activities for …
R Purgatorio, M de Candia, M Catto, A Carrieri… - European Journal of …, 2019 - Elsevier
Due to the role of butyrylcholinesterase (BChE) in acetylcholine hydrolysis in the late stages
of the Alzheimer's disease (AD), inhibitors of butyrylcholinesterase (BChE) have been …
of the Alzheimer's disease (AD), inhibitors of butyrylcholinesterase (BChE) have been …
Chemical polysialylation of human recombinant butyrylcholinesterase delivers a long-acting bioscavenger for nerve agents in vivo
DG Ilyushin, IV Smirnov… - Proceedings of the …, 2013 - National Acad Sciences
The creation of effective bioscavengers as a pretreatment for exposure to nerve agents is a
challenging medical objective. We report a recombinant method using chemical …
challenging medical objective. We report a recombinant method using chemical …