The pathogenic role of angiogenesis in rheumatoid arthritis

HA Elshabrawy, Z Chen, MV Volin, S Ravella… - Angiogenesis, 2015 - Springer
Angiogenesis is the formation of new capillaries from pre-existing vasculature, which plays a
critical role in the pathogenesis of several inflammatory autoimmune diseases such as …

The key players of parthanatos: opportunities for targeting multiple levels in the therapy of parthanatos-based pathogenesis

L Liu, J Li, Y Ke, X Zeng, J Gao, X Ba… - Cellular and Molecular Life …, 2022 - Springer
Parthanatos is a form of regulated cell death involved in the pathogenesis of many diseases,
particularly neurodegenerative disorders, such as Parkinson's disease, Alzheimer's disease …

MIF: a new cytokine link between rheumatoid arthritis and atherosclerosis

EF Morand, M Leech, J Bernhagen - Nature reviews Drug discovery, 2006 - nature.com
Macrophage migration inhibitory factor (MIF) is well established as a key cytokine in immuno-
inflammatory diseases such as rheumatoid arthritis. Inflammation is now also recognized as …

Cell signalling in macrophages, the principal innate immune effector cells of rheumatoid arthritis

SK Drexler, PL Kong, J Wales, BM Foxwell - Arthritis research & therapy, 2008 - Springer
Rheumatoid arthritis is a multisystemic auto-inflammatory disease affecting up to 1% of the
population and leading to the destruction of the joints. Evidence exists for the involvement of …

New insights from single-cell sequencing data: Synovial fibroblasts and synovial macrophages in rheumatoid arthritis

L Cheng, Y Wang, R Wu, T Ding, H Xue, C Gao… - Frontiers in …, 2021 - frontiersin.org
Single-cell RNA sequencing (scRNA-seq) technology can analyze the transcriptome
expression level of cells with high-throughput from the single cell level, fully show the …

Macrophage migration inhibitory factor (MIF): biological activities and relation with cancer

CCG Nobre, JMG de Araújo, TAAM Fernandes… - Pathology & Oncology …, 2017 - Springer
Macrophage migration inhibitory factor (MIF) emerged in recent years as an important
inflammation mediator, playing a prominent role in the pathogenesis of various types of …

Macrophage migration inhibitory factor–CXCR4 is the dominant chemotactic axis in human mesenchymal stem cell recruitment to tumors

S Lourenco, VH Teixeira, T Kalber, RJ Jose… - The Journal of …, 2015 - journals.aai.org
Mesenchymal stromal cells (MSCs) are inherently tumor homing and can be isolated,
expanded, and transduced, making them viable candidates for cell therapy. This tumor …

Curcumin and rheumatoid arthritis: A systematic review of literature

F Pourhabibi‐Zarandi… - … Journal of Clinical …, 2021 - Wiley Online Library
Background Curcumin is a natural polyphenol and the main compound from the rhizome of
Turmeric (Curcuma longa) and other Curcuma species. It has been widely used for different …

MIF, a controversial cytokine: a review of structural features, challenges, and opportunities for drug development

J Bloom, S Sun, Y Al-Abed - Expert opinion on therapeutic targets, 2016 - Taylor & Francis
Introduction: Macrophage migration inhibitory factor (MIF) has emerged as a promising drug
target in diseases including sepsis, rheumatoid arthritis, and cancer. MIF has multiple …

Oxidative stress, kinase activation, and inflammatory pathways involved in effects on smooth muscle cells during pulmonary artery hypertension under hypobaric …

P Siques, E Pena, J Brito, S El Alam - Frontiers in physiology, 2021 - frontiersin.org
High-altitude exposure results in hypobaric hypoxia, which affects organisms by activating
several mechanisms at the physiological, cellular, and molecular levels and triggering the …