Senescence and cancer—role and therapeutic opportunities
Cellular senescence is a state of stable, terminal cell cycle arrest associated with various
macromolecular changes and a hypersecretory, pro-inflammatory phenotype. Entry of cells …
macromolecular changes and a hypersecretory, pro-inflammatory phenotype. Entry of cells …
The landscape of aging
Aging is characterized by a progressive deterioration of physiological integrity, leading to
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …
The metabolic roots of senescence: mechanisms and opportunities for intervention
CD Wiley, J Campisi - Nature Metabolism, 2021 - nature.com
Cellular senescence entails a permanent proliferative arrest, coupled to multiple phenotypic
changes. Among these changes is the release of numerous biologically active molecules …
changes. Among these changes is the release of numerous biologically active molecules …
The role of cellular senescence in cardiac disease: basic biology and clinical relevance
M Mehdizadeh, M Aguilar, E Thorin… - Nature Reviews …, 2022 - nature.com
Cellular senescence, classically defined as stable cell cycle arrest, is implicated in biological
processes such as embryogenesis, wound healing and ageing. Senescent cells have a …
processes such as embryogenesis, wound healing and ageing. Senescent cells have a …
Role of immune cells in the removal of deleterious senescent cells
Cellular senescence is an essentially irreversible arrest of cell proliferation coupled to a
complex senescence-associated secretory phenotype (SASP). The senescence arrest …
complex senescence-associated secretory phenotype (SASP). The senescence arrest …
[HTML][HTML] Cellular senescence in cardiovascular diseases: a systematic review
C Hu, X Zhang, T Teng, ZG Ma, QZ Tang - Aging and disease, 2022 - ncbi.nlm.nih.gov
Aging is a prominent risk factor for cardiovascular diseases, which is the leading cause of
death around the world. Recently, cellular senescence has received potential attention as a …
death around the world. Recently, cellular senescence has received potential attention as a …
Cellular senescence in development, regeneration and disease
M Rhinn, B Ritschka, WM Keyes - Development, 2019 - journals.biologists.com
Cellular senescence is a state comprising an essentially irreversible proliferative arrest
combined with phenotypic changes and pronounced secretory activity. Although …
combined with phenotypic changes and pronounced secretory activity. Although …
The right time for senescence
D Paramos-de-Carvalho, A Jacinto, L Saúde - Elife, 2021 - elifesciences.org
Cellular senescence is a highly complex and programmed cellular state with diverse and, at
times, conflicting physiological and pathological roles across the lifespan of an organism …
times, conflicting physiological and pathological roles across the lifespan of an organism …
Heart regeneration by endogenous stem cells and cardiomyocyte proliferation: controversy, fallacy, and progress
Ischemic heart disease is the leading cause of death worldwide. Myocardial infarction
results in an irreversible loss of cardiomyocytes with subsequent adverse remodeling and …
results in an irreversible loss of cardiomyocytes with subsequent adverse remodeling and …