[HTML][HTML] Machine perfusion for extended criteria donor livers: what challenges remain?

J Widmer, J Eden, MF Carvalho, P Dutkowski… - Journal of Clinical …, 2022 - mdpi.com
Based on the renaissance of dynamic preservation techniques, extended criteria donor
(ECD) livers reclaimed a valuable eligibility in the transplantable organ pool. Being more …

[HTML][HTML] Organ restoration with normothermic machine perfusion and immune reaction

A Parente, DC Osei-Bordom, V Ronca… - Frontiers in …, 2020 - frontiersin.org
Liver transplantation is the only recognized effective treatment for end-stage liver disease.
However, organ shortages have become the main challenge for patients and physicians …

Liver transplantation of partial grafts after ex situ splitting during hypothermic oxygenated perfusion—The HOPE–Split pilot study

G Rossignol, X Muller, V Hervieu… - Liver …, 2022 - Wiley Online Library
Partial liver grafts from ex situ splitting are considered marginal due to prolonged static cold
storage. The use of ex situ hypothermic oxygenated perfusion (HOPE) may offer a strategy to …

Improving outcomes of in situ split liver transplantation in Italy over the last 25 years

A Lauterio, U Cillo, M Spada, S Trapani, R De Carlis… - Journal of …, 2023 - Elsevier
Background & Aims Split liver transplant (ation)(SLT) is still considered a challenging
procedure that is by no means widely accepted. We aimed to present data on 25-year trends …

[HTML][HTML] Ex situ dual hypothermic oxygenated machine perfusion for human split liver transplantation

AM Thorne, V Lantinga, S Bodewes… - Transplantation …, 2021 - journals.lww.com
Background. Liver splitting allows the opportunity to share a deceased graft between 2
recipients but remains underutilized. We hypothesized that liver splitting during continuous …

[HTML][HTML] Liver splitting during normothermic machine perfusion: a novel method to combine the advantages of both in-situ and ex-vivo techniques

NS Lau, M Ly, C Dennis, K Ewenson, H Ly, JL Huang… - HPB, 2023 - Elsevier
Background Split liver transplantation permits the transplant of two recipients using a single
donor liver. Liver splitting can be performed using the ex-vivo technique (more convenient) …

[HTML][HTML] Beneficial effects of end-ischemic oxygenated machine perfusion preservation for split-liver transplantation in recovering graft function and reducing ischemia …

D Ishii, N Matsuno, M Gochi, H Iwata, T Shonaka… - Scientific Reports, 2021 - nature.com
This study examined the efficacy of end-ischemic hypothermic oxygenated machine
perfusion preservation (HOPE) using an originally developed machine perfusion system for …

Ex vivo liver splitting and hypothermic oxygenated machine perfusion: technical refinements of a promising preservation strategy in split liver transplantation

JY Mabrut, M Lesurtel, X Muller, R Dubois… - …, 2021 - journals.lww.com
J.-YM designed the research, performed the research, and wrote the article. ML and GR
performed the research and participated in writing the article. XM and RD participated in …

Addressing the challenges of split liver transplantation through technical advances. A systematic review

NS Lau, A Jacques, G McCaughan, M Crawford… - Transplantation …, 2021 - Elsevier
Background Split liver transplantation addresses donor shortages by facilitating the
transplant of two recipients using one donor liver. Some still consider these grafts inferior …

Efficiency of machine perfusion in pediatric liver transplantation

A Parente, M Kasahara, VE De Meijer… - Liver …, 2024 - journals.lww.com
Liver transplantation is the only lifesaving procedure for children with end-stage liver
disease. The field is however heterogenic with various graft types, recipient age and weight …