The interest in 3, 4-dihydropyrimidine-2 (1 H)-(thio) ones is increasing every day, mainly due
to their paramount biological relevance. The Biginelli reaction is the classical approach to …

Breast cancer is one of the most prevalent malignant diseases, and one of the main causes
of mortality among women across the world. Despite advances in chemotherapy, drug …

In this study, we report on antiproliferative benzyloxy dihydropyrimidinones (DHPMs)
produced by the Biginelli reaction of benzyloxy benzaldehyde, urea, and diverse 1, 3 …

Molecular hybridization approaches have become an important strategy in medicinal
chemistry, and to this end, we have developed a series of novel N-1, 2, 3-triazole–isatin …

New hybrid compounds belonging to the class of 1, 4-disubstituted 1, 2, 3-triazoles were
synthesized. The structural characterization of the synthesized compounds was performed …

Condensation reaction of phenyl acetyl isothiocyanate (1) and phenyl hydrazine was
performed to obtain 1-phenyl-4-(2-phenylacetyl) thiosemicarbazide (2). Compound (2) was …

Cancer is a serious disease that has been around for a long time but currently has no
sustainable solution. Several medications currently available offer an opportunity for the …

Introduction The concept of click chemistry was introduced in 2001 as an effective, efficient,
and sustainable approach to making functional groups harnessing the thermodynamic …

Breast cancer, as one of the most common invasive malignancies and the leading cause of
cancer‐related deaths in women globally, poses a significant challenge in the world health …

Multicomponent reactions (MCRs) represent very interesting tools to reach eco-friendly and
sustainable transformations in organic chemistry. In particular, the Biginelli reaction …