Type 1 diabetes (T1D) results from destruction of pancreatic beta cells by T cells of the
immune system. Despite improvements in insulin analogs and continuous blood glucose …

Inflammation is an integral part of autoimmune diseases, which are caused by dysregulation
of the immune system. This dysregulation involves an imbalance between pro-inflammatory …

Type 1 diabetes (T1D) is a chronic autoimmune disease in which destruction or damaging of
the beta-cells in the islets of Langerhans results in insulin deficiency and hyperglycemia. We …

Low-grade intestinal inflammation and alterations of gut barrier integrity are found in patients
affected by extraintestinal autoimmune diseases such as type 1 diabetes (T1D), but a direct …

Structural similarity between viral T cell epitopes and self-peptides could lead to the
induction of an autoaggressive T cell response. Based on the structural requirements for …

Insulin-dependent diabetes mellitus (IDDM) is a chronic disorder that results from
autoimmune destruction of the insulin-producing pancreatic beta cells. Much has been …

▪ Abstract Autoimmunity is a complex process that likely results from the summation of
multiple defective tolerance mechanisms. The NOD mouse strain is an excellent model of …

Evidence continues to accumulate supporting the hypothesis that tissue damage during an
immune response can lead to the priming of self-reactive T and/or B lymphocytes …

As a group of disorders, autoimmunity ranks as the third most prevalent cause of morbidity
and mortality in the W estern W orld. However, the etiology of most autoimmune diseases …

The development of lymphoid organs can be viewed as a continuum. At one end are
the'canonical'secondary lymphoid organs, including lymph nodes and spleen; at the other …