A healthy aorta exerts a powerful cushioning function, which limits arterial pulsatility and
protects the microvasculature from potentially harmful fluctuations in pressure and blood …

Early detection of subclinical atherosclerosis is important to reduce patients' cardiovascular
risk. However, current diagnostic strategy focusing on traditional risk factors or using risk …

Background—Age-related dementia, most commonly caused by Alzheimer disease or
cerebrovascular factors (vascular dementia), is a major public health threat. Chronic arterial …

Townsend et al Vascular Research on Arterial Stiffness 699 pressure, blood flow, and
arterial diameter change with each heartbeat. In addition to the passive mechanical …

Background and Purpose—This scientific statement provides an overview of the evidence
on vascular contributions to cognitive impairment and dementia. Vascular contributions to …

The incidence of dementia and cardiovascular disease (CVD) increases with age. Current
evidence supports the role for both atherosclerosis and arteriosclerosis as a common …

Aortic stiffness increases with age and vascular risk factor exposure and is associated with
increased risk for structural and functional abnormalities in the brain. High ambient flow and …

The brain is highly dependent on an adequate delivery of oxygen and glucose from the
circulation, and cerebral blood flow (CBF) reductions impair neuronal function and, if …

The process of aging includes changes in cellular biology that affect local interactions
between cells and their environments and eventually propagate to systemic levels. In the …

Background and Purpose—Arterial stiffening reduces damping of the arterial waveform and
hence increases pulsatility of cerebral blood flow, potentially damaging small vessels. In the …