Glucocorticoid action on target tissues is determined by the density of “nuclear” receptors
and intracellular metabolism by the two isozymes of 11β-hydroxysteroid dehydrogenase …

Mechanisms of Glucocorticoid-Induced Insulin Resistance - Endocrinology and Metabolism
Clinics Skip to Main Content Skip to Main Menu Advertisement Endocrinology and …

Adipose tissue is a highly heterogeneous endocrine organ. The heterogeneity among
different anatomical depots stems from their intrinsic differences in cellular and physiological …

Central obesity is associated with insulin resistance and dyslipidemia. Thus, the
mechanisms that control fat distribution and its impact on systemic metabolism have …

Chronic excessive activation of glucocorticoid receptors induces obesity, insulin resistance,
glucose intolerance, dyslipidaemia and hypertension. Subtle abnormalities of the …

OBJECTIVE The mammalian target of rapamycin (mTOR)/p70 S6 kinase 1 (S6K1) pathway
is a critical signaling component in the development of obesity-linked insulin resistance and …

Estrogen affects proliferation and migration of different skin components, thus influencing
wound healing processes. The human keratinocyte cell line NCTC 2544 has been used to …

Adamantyl-based compounds are used clinically for the treatment of neurological
conditions, as anti-viral agents and as agents against type 2 diabetes. The value of the …

OBJECTIVE 11-β-hydroxysteroid dehydrogenase type 1 (11βHSD1) converts inactive
cortisone into active cortisol, thereby amplifying intracellular glucocorticoid action. The …

In recent years, we've developed a much better grasp of the biological and other factors
associated with the development of obesity. Reflecting our evolving understanding of …