The development of neoplasia involves a complex and continuous interplay between
malignantly transformed cells and the tumour microenvironment (TME). Cancer …

Diabetes is associated with an altered global inflammatory state with impaired wound
healing. Mesenchymal stem/stromal cells (MSC) are being explored for treatment of diabetic …

B cell immunity has a penetrating effect on human health and diseases. Therapeutics aiming
to modulate B cell immunity have achieved remarkable success in combating infections …

Heterogeneity in the tumor microenvironment (TME) of follicular lymphomas (FLs) can affect
clinical outcomes. Current immunotherapeutic strategies, including antibody-and cell-based …

Recreating human tissues and organs in the petri dish to establish models as tools in
biomedical sciences has gained momentum. These models can provide insight into …

A strategy combining targeted therapies is effective in B-cell lymphomas (BCL), such as
mantle cell lymphoma (MCL), but acquired resistances remain a recurrent issue. In this …

Cellular programming of naïve T cells can improve the efficacy of adoptive T-cell therapy.
However, the current ex vivo engineering of T cells requires the pre-activation of T cells …

B-cell lymphomas are a group of heterogeneous neoplasms resulting from the clonal
expansion of mature B cells arrested at various stages of differentiation. Specifically, two …

Chromosome gains or losses often lead to copy number variations (CNV) and loss of
heterozygosity (LOH). Both quantities are low in hematologic “liquid” cancers versus solid …

For over two decades, Rituximab and CHOP combination treatment (rCHOP) has remained
the standard treatment approach for diffuse large B-cell lymphoma (DLBCL). Despite …