Dipeptidyl-peptidase IV from bench to bedside: an update on structural properties, functions, and clinical aspects of the enzyme DPP IV

AM Lambeir, C Durinx, S Scharpé… - Critical reviews in …, 2003 - Taylor & Francis
Dipeptidyl-peptidase IV/CD26 (DPP IV) is a cell-surface protease belonging to the
prolyloligopeptidase family. It selectively removes the N-terminal dipeptide from peptides …

Boron containing compounds as protease inhibitors

R Smoum, A Rubinstein, VM Dembitsky… - Chemical …, 2012 - ACS Publications
Proteases form one of the largest and more important groups of enzymes. They selectively
catalyze the hydrolysis of peptide bonds and can be divided into four major classes …

Internalization of HIV-1 tat requires cell surface heparan sulfate proteoglycans

M Tyagi, M Rusnati, M Presta, M Giacca - Journal of Biological Chemistry, 2001 - ASBMB
Tat, the transactivator protein of human immunodeficiency virus-1, has the unusual capacity
of being internalized by cells when present in the extracellular milieu. This property can be …

The multifunctional or moonlighting protein CD26/DPPIV

E Boonacker, CJF Van Noorden - European journal of cell biology, 2003 - Elsevier
CD26/DPPIV can be considered a moonlighting protein because it is a multifunctional
protein that exerts its different functions depending on cell type and intra-or extracellular …

CD26: a multifunctional integral membrane and secreted protein of activated lymphocytes

MD Gorrell, V Gysbers… - Scandinavian journal of …, 2001 - Wiley Online Library
CD26 has proved interesting in the fields of immunology, endocrinology, cancer biology and
nutrition owing to its ubiquitous and unusual enzyme activity. This dipeptidyl …

The structure and function of CD26 in the T‐cell immune response

C Morimoto, SF Schlossman - Immunological reviews, 1998 - Wiley Online Library
CD26 is a widely distributed 110 kD cell‐surface glycoprotein with known dipeptidyl‐
peptidase IV (DPP‐IV) activity in its extracellular domain. This ectoenzyme is capable of …

CD26: a surface protease involved in T-cell activation

B Fleischer - Immunology today, 1994 - cell.com
CD26~ sa proteolytlc enzyme (&pepttdylpeptl&tse IV) u'tth au, lde tissue distribution, lnd a
umque speoficit3: Recent developments m&cate that CD26 zs a multlfi, lCttonal molecule …

Control of SHIV-89.6 P-infection of cynomolgus monkeys by HIV-1 Tat protein vaccine

A Cafaro, A Caputo, C Fracasso, MT Maggiorella… - Nature medicine, 1999 - nature.com
Vaccine strategies aimed at blocking virus entry have so far failed to induce protection
against heterologous viruses. Thus, the control of viral infection and the block of disease …

[HTML][HTML] The unique properties of dipeptidyl-peptidase IV (DPP IV/CD26) and the therapeutic potential of DPP IV inhibitors

ÁM Bollaerta, C Durinxb, F Goossensb… - Curr. Med …, 1999 - books.google.com
This review deals with the properties and functions of dipeptidyl peptidase IV (DPP IV, EC
3.4. 14.5). This membrane anchored ecto-protease has been identified as the leukocyte …

Induction of the chemokines interleukin-8 and IP-10 by human immunodeficiency virus type 1 tat in astrocytes

O Kutsch, JW Oh, A Nath, EN Benveniste - Journal of virology, 2000 - Am Soc Microbiol
ABSTRACT A finding commonly observed in human immunodeficiency virus type 1 (HIV-1)-
infected patients is invasion of the brain by activated T cells and infected macrophages …