Antigen presentation by major histocompatibility complex (MHC) proteins is essential for
adaptive immunity. Prior to presentation, peptides need to be generated from proteins that …

Presentation of peptide antigens by MHC-II proteins is prerequisite to effective CD4 T cell
tolerance to self and to recognition of foreign antigens. Antigen uptake and processing …

Presentation of antigenic peptides by major histocompatibility complex class II (MHC-II)
proteins determines T helper cell reactivity. The MHC-II genetic locus displays a large …

T cell receptor (TCR) recognition of antigenic peptides bound and presented by class I major
histocompatibility complex (MHC) proteins underlies the cytotoxic immune response to …

Molecular mimicry between foreign and self-antigens has been implicated as a cause of
autoimmune hepatitis in experimental models and cross-reacting antibodies in patients. This …

Dendritic cells are the antigen presenting cells that process antigens effectively and prime
the immune system, a characteristic that have gained them the spotlights in recent years. B …

Structural biology of peptides presented by class I and class II MHC proteins has
transformed immunology, impacting our understanding of fundamental immune mechanisms …

The presentation of peptide-MHCII complexes (pMHCIIs) for surveillance by T cells is a well-
known immunological concept in vertebrates, yet the conformational dynamics of antigen …

Binding prediction tools are commonly used to identify peptides presented on MHC class II
molecules. Recently, a wealth of data in the form of naturally eluted ligands has become …

T cell antigen receptors (TCRs) expressed on cytotoxic or helper T cells can only see their
specific target antigen as short sequences of peptides bound to the groove of proteins of …