A pivotal role for excitotoxicity in neurodegenerative diseases is gaining increasingly more
acceptance, but the underlying mechanisms through which it participates in …

Down syndrome (DS) is caused by trisomy of chromosome 21 (Hsa21) and is associated
with a number of deleterious phenotypes, including learning disability, heart defects, early …

Abstract Alzheimer's disease (AD), the most common progressive neurodegenerative
disorder, is characterized by severe cognitive decline and personality changes as a result of …

Abstract Trisomy 21 (T21) causes Down syndrome and an early-onset form of Alzheimer's
disease (AD). Here, we used human induced pluripotent stem cells (hiPSCs) along with …

Understanding how cognitive processes including learning, memory, decision making and
ideation are encoded by the genome is a key question in biology. Identification of sets of …

All tauopathies, including Alzheimer's disease (AD), are characterized by the intracellular
accumulation of abnormal forms of tau protein in neurons and glial cells, which negatively …

The ongoing epidemics of metabolic diseases and increase in the older population have
increased the incidences of neurodegenerative diseases. Evidence from murine and cell …

Individuals with Down syndrome (DS) will inevitably develop Alzheimer disease (AD)
neuropathology sometime after middle age, which may be attributable to genes triplicated in …

Down syndrome (DS) is a developmental disorder associated with mental retardation (MR)
and early onset Alzheimer's disease (AD). These CNS phenotypes are attributed to ongoing …

Genomically identical cells have long been assumed to comprise the human brain, with post-
genomic mechanisms giving rise to its enormous diversity, complexity, and disease …