Preclinical applications of multi-platform imaging in animal models of cancer
In animal models of cancer, oncologic imaging has evolved from a simple assessment of
tumor location and size to sophisticated multimodality exploration of molecular, physiologic …
tumor location and size to sophisticated multimodality exploration of molecular, physiologic …
[HTML][HTML] Non-invasive evaluation of acute effects of tubulin binding agents: a review of imaging vascular disruption in tumors
Tumor vasculature proliferates rapidly, generally lacks pericyte coverage, and is uniquely
fragile making it an attractive therapeutic target. A subset of small-molecule tubulin binding …
fragile making it an attractive therapeutic target. A subset of small-molecule tubulin binding …
Hypoxia-activated prodrug evofosfamide treatment in pancreatic ductal adenocarcinoma xenografts alters the tumor redox status to potentiate radiotherapy
S Kishimoto, JR Brender… - Antioxidants & Redox …, 2021 - liebertpub.com
Aims: In hypoxic tumor microenvironments, the strongly reducing redox environment
reduces evofosfamide (TH-302) to release a cytotoxic bromo-isophosphoramide (Br-IPM) …
reduces evofosfamide (TH-302) to release a cytotoxic bromo-isophosphoramide (Br-IPM) …
Oxygen-sensitive MRI: a predictive imaging biomarker for tumor radiation response?
Purpose To develop a noninvasive prognostic imaging biomarker related to hypoxia to
predict SABR tumor control. Methods and Materials A total of 145 subcutaneous syngeneic …
predict SABR tumor control. Methods and Materials A total of 145 subcutaneous syngeneic …
[HTML][HTML] Quantifying reoxygenation in pancreatic cancer during stereotactic body radiotherapy
Hypoxia, the state of low oxygenation that often arises in solid tumours due to their high
metabolism and irregular vasculature, is a major contributor to the resistance of tumours to …
metabolism and irregular vasculature, is a major contributor to the resistance of tumours to …
T1 based oxygen-enhanced MRI in tumours; a scoping review of current research
Objective: Oxygen-enhanced MRI (OE-MRI) or tissue oxygen-level dependent (TOLD) MRI
is an imaging technique under investigation for its ability to quantify and map oxygen …
is an imaging technique under investigation for its ability to quantify and map oxygen …
[HTML][HTML] Hyperoxic BOLD-MRI-Based Characterization of Breast Cancer Molecular Subtypes Is Independent of the Supplied Amount of Oxygen: A Preclinical Study
SJ Bartsch, V Ehret, J Friske, V Fröhlich… - Diagnostics, 2023 - mdpi.com
Hyperoxic BOLD-MRI targeting tumor hypoxia may provide imaging biomarkers that
represent breast cancer molecular subtypes without the use of injected contrast agents …
represent breast cancer molecular subtypes without the use of injected contrast agents …
A general model to calculate the spin–lattice relaxation rate (R1) of blood, accounting for hematocrit, oxygen saturation, oxygen partial pressure, and magnetic field …
Background Under normal physiological conditions, the spin–lattice relaxation rate (R1) in
blood is influenced by many factors, including hematocrit, field strength, and the …
blood is influenced by many factors, including hematocrit, field strength, and the …
[HTML][HTML] Using variable FLIP angle (VFA) and modified look-locker inversion recovery (MOLLI) T1 mapping in clinical OE-MRI
E Bluemke, A Bertrand, KY Chu, N Syed… - Magnetic Resonance …, 2022 - Elsevier
Background and purpose The imaging technique known as Oxygen-Enhanced MRI is under
development as a noninvasive technique for imaging hypoxia in tumours and pulmonary …
development as a noninvasive technique for imaging hypoxia in tumours and pulmonary …
pO2 reporter composite hydrogel macroencapsulation devices for magnetic resonance imaging oxygen quantification
AE Emerson, Y Sugamura, J Mazboudi… - … Research Part A, 2024 - Wiley Online Library
Hydrogel cell encapsulation devices are a common approach to reduce the need for chronic
systemic immunosuppression in allogeneic cell product transplantation …
systemic immunosuppression in allogeneic cell product transplantation …